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. 1989 Oct;27(10):2180–2183. doi: 10.1128/jcm.27.10.2180-2183.1989

Seroepidemiology of adult diarrhea rotavirus in China, 1977 to 1987.

M E Penaranda 1, M S Ho 1, Z Y Fang 1, H Dong 1, X S Bai 1, S C Duan 1, W W Ye 1, M K Estes 1, P Echeverria 1, T Hung 1, et al.
PMCID: PMC266989  PMID: 2479654

Abstract

In 1982, large outbreaks of diarrhea that were caused by group B adult diarrhea rotavirus (ADRV) occurred throughout the People's Republic of China. Until 1982, group B rotavirus had never been associated with disease in humans. To determine whether ADRV was a new virus introduced in 1982 or had been present before that time, we examined antibody titers of ADRV in gamma globulin (pooled immunoglobulin) pools that were prepared during 1977 to 1987 in four cities in the People's Republic of China (Shanghai, Lanzhou, Wuhan, and Chandu). ADRV antibodies were assayed by using a blocking enzyme-linked immunosorbent assay. Antibodies were present in most Chinese gamma globulins tested, including those collected in Shanghai before the 1982 epidemic, and absent from American reference pools. The highest titers of antibody to ADRV (3,200) were found in gamma globulins collected in 1983 in Shanghai just after the epidemic, and these were fourfold higher than titers present in the preceding years. The quality of the gamma globulins stored for up to 12 years was tested by measuring levels of immunoglobulin G to group A rotavirus; these were equally high in gamma globulin pools prepared in the United States and in all samples from the People's Republic of China. Serum samples from patients from an outbreak of ADRV had elevated titers to ADRV 3 and 16 months after the onset of symptoms. These findings, as well as other epidemiologic findings on ADRV, suggest that the organism is an important and continuing cause of diarrhea in the People's Republic of China, was present before the first epidemic in 1982, and represents a risk to surrounding populations in Asia.

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Selected References

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  1. Bridger J. C., Brown J. F. Prevalence of antibody to typical and atypical rotaviruses in pigs. Vet Rec. 1985 Jan 12;116(2):50–50. doi: 10.1136/vr.116.2.50. [DOI] [PubMed] [Google Scholar]
  2. Bridger J. C. Novel rotaviruses in animals and man. Ciba Found Symp. 1987;128:5–23. doi: 10.1002/9780470513460.ch2. [DOI] [PubMed] [Google Scholar]
  3. Bridger J. C., Pedley S., McCrae M. A. Group C rotaviruses in humans. J Clin Microbiol. 1986 Apr;23(4):760–763. doi: 10.1128/jcm.23.4.760-763.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brown D. W., Beards G. M., Chen G. M., Flewett T. H. Prevalence of antibody to group B (atypical) rotavirus in humans and animals. J Clin Microbiol. 1987 Feb;25(2):316–319. doi: 10.1128/jcm.25.2.316-319.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chen C. M., Hung T., Bridger J. C., McCrae M. A. Chinese adult rotavirus is a group B rotavirus. Lancet. 1985 Nov 16;2(8464):1123–1124. doi: 10.1016/s0140-6736(85)90710-x. [DOI] [PubMed] [Google Scholar]
  6. Dai G. Z., Sun M. S., Liu S. Q., Ding X. F., Chen Y. D., Wang L. C., Du D. P., Zhao G., Su Y., Li J. First report of an epidemic of diarrhoea in human neonates involving the new rotavirus and biological characteristics of the epidemic virus strain (KMB/R85). J Med Virol. 1987 Aug;22(4):365–373. doi: 10.1002/jmv.1890220409. [DOI] [PubMed] [Google Scholar]
  7. Eiden J., Vonderfecht S., Yolken R. H. Evidence that a novel rotavirus-like agent of rats can cause gastroenteritis in man. Lancet. 1985 Jul 6;2(8445):8–11. doi: 10.1016/s0140-6736(85)90057-1. [DOI] [PubMed] [Google Scholar]
  8. Estes M. K., Palmer E. L., Obijeski J. F. Rotaviruses: a review. Curr Top Microbiol Immunol. 1983;105:123–184. doi: 10.1007/978-3-642-69159-1_3. [DOI] [PubMed] [Google Scholar]
  9. Fang Z. Y., Deng S. S., Wang C. A., Ye W. W., Chen G. M., Chi J., Hong T. [Analysis of the genome of rotavirus from the feces of adult infectious diarrhea]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1985 Apr;7(2):93–96. [PubMed] [Google Scholar]
  10. Fang Z. Y., Glass R. I., Penaranda M., Dong H., Monroe S. S., Wen L., Estes M. K., Eiden J., Yolken R. H., Saif L. Purification and characterization of adult diarrhea rotavirus: identification of viral structural proteins. J Virol. 1989 May;63(5):2191–2197. doi: 10.1128/jvi.63.5.2191-2197.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hung T., Chen G. M., Wang C. G., Fan R. L., Yong R. J., Chang J. Q., Dan R., Ng M. H. Seroepidemiology and molecular epidemiology of the Chinese rotavirus. Ciba Found Symp. 1987;128:49–62. doi: 10.1002/9780470513460.ch4. [DOI] [PubMed] [Google Scholar]
  12. Hung T., Chen G. M., Wang C. G., Yao H. L., Fang Z. Y., Chao T. X., Chou Z. Y., Ye W., Chang X. J., Den S. S. Waterborne outbreak of rotavirus diarrhoea in adults in China caused by a novel rotavirus. Lancet. 1984 May 26;1(8387):1139–1142. [PubMed] [Google Scholar]
  13. Hung T., Fan R. L., Wang C. A., Chen G. M., Chou D. N., Chang J. Q., McCrae M. A., Wang W. Z., Se W. Z., Dan R. Seroepidemiology of adult rotavirus. Lancet. 1985 Aug 10;2(8450):325–326. [PubMed] [Google Scholar]
  14. Nakata S., Estes M. K., Graham D. Y., Wang S. S., Gary G. W., Melnick J. L. Detection of antibody to group B adult diarrhea rotaviruses in humans. J Clin Microbiol. 1987 May;25(5):812–818. doi: 10.1128/jcm.25.5.812-818.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pedley S., Bridger J. C., Brown J. F., McCrae M. A. Molecular characterization of rotaviruses with distinct group antigens. J Gen Virol. 1983 Oct;64(Pt 10):2093–2101. doi: 10.1099/0022-1317-64-10-2093. [DOI] [PubMed] [Google Scholar]
  16. Pedley S., Bridger J. C., Chasey D., McCrae M. A. Definition of two new groups of atypical rotaviruses. J Gen Virol. 1986 Jan;67(Pt 1):131–137. doi: 10.1099/0022-1317-67-1-131. [DOI] [PubMed] [Google Scholar]
  17. Qiu F. X., Tian Y., Liu J. C., Zhang X. S., Hao Y. P. Antibody against adult diarrhoea rotavirus among healthy adult population in China. J Virol Methods. 1986 Sep;14(2):127–132. doi: 10.1016/0166-0934(86)90043-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Qiu F. X., Tian Y., Xu A. Y., Liu J. C., Li F. S. RNA genome electrophoretic analysis of rotavirus from feces of epidemic adult diarrhoea occurring in Shandong Province, China. J Diarrhoeal Dis Res. 1985 Jun;3(2):73–77. [PubMed] [Google Scholar]
  19. Su C. Q., Wu Y. L., Shen H. K., Wang D. B., Chen Y. H., Wu D. M., He L. N., Yang Z. L. An outbreak of epidemic diarrhoea in adults caused by a new rotavirus in Anhui Province of China in the summer of 1983. J Med Virol. 1986 Jun;19(2):167–173. doi: 10.1002/jmv.1890190210. [DOI] [PubMed] [Google Scholar]
  20. Tao H. Rotavirus and adult diarrhea. Adv Virus Res. 1988;35:193–218. [PubMed] [Google Scholar]
  21. Wang C. A., Yang R. J., Chen G. M., Wang J. L., Xiong J. Y., Liu H. M., Hung T. [Molecular epidemiological study of ADRV from 12 outbreaks]. Wei Sheng Wu Xue Bao. 1985 Jun;25(2):153–157. [PubMed] [Google Scholar]
  22. Wang S. S., Cai R. F., Chen J., Li R. J., Jiang R. S. Etiologic studies of the 1983 and 1984 outbreaks of epidemic diarrhea in Guangxi. Intervirology. 1985;24(3):140–146. doi: 10.1159/000149633. [DOI] [PubMed] [Google Scholar]
  23. Yolken R. H., Wyatt R. G., Kim H. W., Kapikian A. Z., Chanock R. M. Immunological response to infection with human reovirus-like agent: measurement of anti-human reovirus-like agent immunoglobulin G and M levels by the method of enzyme-linked immunosorbent assay. Infect Immun. 1978 Feb;19(2):540–546. doi: 10.1128/iai.19.2.540-546.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]

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