Abstract
A case of bacteremia caused by a multiresistant strain of Capnocytophaga sputigena in a patient with hematological malignancy is described. The strain presented with a pattern of marked resistance to beta-lactams, with MICs of > 256 mg/liter for ampicillin, ticarcillin, piperacillin, cefazolin, and cefuroxime, 64 mg/liter for cefotaxime, and 32 mg/liter for ceftazidime. In addition, the MIC of ciprofloxacin was 16 mg/liter. Both of these groups of antimicrobial agents are frequently used in the empiric treatment of infections in immunocompromised patients. The appearance of resistant strains suggests the need for antimicrobial susceptibility studies in all patients with severe infections caused by Capnocytophaga spp. or other capnophilic organisms present in the oral microflora of these patients.
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- Arlet G., Sanson-Le Pors M. J., Casin I. M., Ortenberg M., Perol Y. In vitro susceptibility of 96 Capnocytophaga strains, including a beta-lactamase producer, to new beta-lactam antibiotics and six quinolones. Antimicrob Agents Chemother. 1987 Aug;31(8):1283–1284. doi: 10.1128/aac.31.8.1283. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Baquero F., Fernández J., Dronda F., Erice A., Pérez de Oteiza J., Reguera J. A., Reig M. Capnophilic and anaerobic bacteremia in neutropenic patients: an oral source. Rev Infect Dis. 1990 Jan-Feb;12 (Suppl 2):S157–S160. doi: 10.1093/clinids/12.supplement_2.s157. [DOI] [PubMed] [Google Scholar]
- Forlenza S. W., Newman M. G., Lipsey A. I., Siegel S. E., Blachman U. Capnocytophaga sepsis: a newly recognised clinical entity in granulocytopenic patients. Lancet. 1980 Mar 15;1(8168 Pt 1):567–568. doi: 10.1016/s0140-6736(80)91057-0. [DOI] [PubMed] [Google Scholar]
- Foweraker J. E., Hawkey P. M., Heritage J., Van Landuyt H. W. Novel beta-lactamase from Capnocytophaga sp. Antimicrob Agents Chemother. 1990 Aug;34(8):1501–1504. doi: 10.1128/aac.34.8.1501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Newman M. G., Socransky S. S., Savitt E. D., Propas D. A., Crawford A. Studies of the microbiology of periodontosis. J Periodontol. 1976 Jul;47(7):373–379. doi: 10.1902/jop.1976.47.7.373. [DOI] [PubMed] [Google Scholar]
- Newman M. G., Sutter V. L., Pickett M. J., Blachman U., Greenwood J. R., Grinenko V., Citron D. Detection, identification, and comparison of Capnocytophaga, Bacteroides ochraceus, and DF-1. J Clin Microbiol. 1979 Oct;10(4):557–562. doi: 10.1128/jcm.10.4.557-562.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parenti D. M., Snydman D. R. Capnocytophaga species: infections in nonimmunocompromised and immunocompromised hosts. J Infect Dis. 1985 Jan;151(1):140–147. doi: 10.1093/infdis/151.1.140. [DOI] [PubMed] [Google Scholar]
- Roscoe D. L., Zemcov S. J., Thornber D., Wise R., Clarke A. M. Antimicrobial susceptibilities and beta-lactamase characterization of Capnocytophaga species. Antimicrob Agents Chemother. 1992 Oct;36(10):2197–2200. doi: 10.1128/aac.36.10.2197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rummens J. L., Gordts B., Van Landuyt H. W. In vitro susceptibility of Capnocytophaga species to 29 antimicrobial agents. Antimicrob Agents Chemother. 1986 Nov;30(5):739–742. doi: 10.1128/aac.30.5.739. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams B. L., Hollis D., Holdeman L. V. Synonymy of strains of Center for Disease Control group DF-1 with species of Capnocytophaga. J Clin Microbiol. 1979 Oct;10(4):550–556. doi: 10.1128/jcm.10.4.550-556.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]