Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1989 Jan;27(1):62–65. doi: 10.1128/jcm.27.1.62-65.1989

Immunoglobulin G subclass antibodies to measles virus in patients with subacute sclerosing panencephalitis or multiple sclerosis.

P D Mehta 1, B A Patrick 1, W Sobczyk 1, J Kulczycki 1, J Woyciechowska-Camenga 1, D Camenga 1, H Thormar 1
PMCID: PMC267233  PMID: 2913037

Abstract

Mouse monoclonal antibodies specific for human immunoglobulin G (IgG) subclasses and a sensitive immunoassay were used to evaluate the IgG subclass antibody response to measles virus antigens in cerebrospinal fluid and serum samples from 20 patients with subacute sclerosing panencephalitis (SSPE), 12 patients with multiple sclerosis (MS), and 11 controls with high measles virus antibody titers in serum. In patients with SSPE, measles virus-specific antibodies were found mainly in the IgG1 subclass and the IgG subclass distribution remained unchanged, irrespective of the clinical stage or duration of the disease. In patients with MS and in controls, measles virus activity was also associated mainly with IgG1. However, the activity was significantly lower than that found in patients with SSPE. The results suggest that there is no primary abnormality in humoral immune response to measles virus in patients with MS. The disproportionately high levels of the measles virus-specific IgG1 subclass found in patients with SSPE may be due to persistent antigenic stimulation or reflect a defect in immunoregulatory mechanisms in response to viral infection.

Full text

PDF
62

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett D. J., Ayoub E. M. IgG2 subclass restriction of antibody to pneumococcal polysaccharides. Clin Exp Immunol. 1986 Jan;63(1):127–134. [PMC free article] [PubMed] [Google Scholar]
  2. Coleman R. M., Nahmias A. J., Williams S. C., Phillips D. J., Black C. M., Reimer C. B. IgG subclass antibodies to herpes simplex virus. J Infect Dis. 1985 May;151(5):929–936. doi: 10.1093/infdis/151.5.929. [DOI] [PubMed] [Google Scholar]
  3. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  4. Haddad F. S., Risk W. S. Isoprinosine treatment in 18 patients with subacute sclerosing panencephalitis: a controlled study. Ann Neurol. 1980 Feb;7(2):185–188. doi: 10.1002/ana.410070216. [DOI] [PubMed] [Google Scholar]
  5. Horta-Barbosa L., Fuccillo D. A., Sever J. L., Zeman W. Subacute sclerosing panencephalitis: isolation of measles virus from a brain biopsy. Nature. 1969 Mar 8;221(5184):974–974. doi: 10.1038/221974a0. [DOI] [PubMed] [Google Scholar]
  6. Hussain R., Grögl M., Ottesen E. A. IgG antibody subclasses in human filariasis. Differential subclass recognition of parasite antigens correlates with different clinical manifestations of infection. J Immunol. 1987 Oct 15;139(8):2794–2798. [PubMed] [Google Scholar]
  7. Jefferis R., Reimer C. B., Skvaril F., de Lange G., Ling N. R., Lowe J., Walker M. R., Phillips D. J., Aloisio C. H., Wells T. W. Evaluation of monoclonal antibodies having specificity for human IgG sub-classes: results of an IUIS/WHO collaborative study. Immunol Lett. 1985;10(3-4):223–252. doi: 10.1016/0165-2478(85)90082-3. [DOI] [PubMed] [Google Scholar]
  8. Linde G. A., Hammarström L., Persson M. A., Smith C. I., Sundqvist V. A., Wahren B. Virus-specific antibody activity of different subclasses of immunoglobulins G and A in cytomegalovirus infections. Infect Immun. 1983 Oct;42(1):237–244. doi: 10.1128/iai.42.1.237-244.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Link H., Panelius M., Salmi A. A. Immunoglobulins and measles antibodies in subacute sclerosing panencephalitis. Arch Neurol. 1973 Jan;28(1):23–30. doi: 10.1001/archneur.1973.00490190041004. [DOI] [PubMed] [Google Scholar]
  10. Mehta P. D., Kane A., Thormar H. Quantitation of measles virus-specific immunoglobulins in serum, CSF, and brain extract from patients with subactue sclerosing panencephalitis. J Immunol. 1977 Jun;118(6):2254–2261. [PubMed] [Google Scholar]
  11. Mehta P. D., Kane A., Thormar H. Relationship between homogeneous IgG fractions and measles virus antibody activities in subacute sclerosing panencephalitis brain. J Immunol. 1976 Dec;117(6):2053–2060. [PubMed] [Google Scholar]
  12. Mehta P. D., Thormar H., Wisniewski H. M. Quantitation of measles-specific IgG. Its presence in CSF and brain extracts of patients with multiple sclerosis. Arch Neurol. 1980 Oct;37(10):607–609. doi: 10.1001/archneur.1980.00500590031002. [DOI] [PubMed] [Google Scholar]
  13. Morell A., Roth-Wicky B., Skvaril F. Immunoglobulin G subclass restriction of antibodies against hepatitis B surface antigen. Infect Immun. 1983 Feb;39(2):565–568. doi: 10.1128/iai.39.2.565-568.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rath S., Devey M. E. IgG subclass composition of antibodies to HBsAg in circulating immune complexes from patients with hepatitis B virus infections. Clin Exp Immunol. 1988 Apr;72(1):164–167. [PMC free article] [PubMed] [Google Scholar]
  15. Rubin R. L., Tang F. L., Chan E. K., Pollard K. M., Tsay G., Tan E. M. IgG subclasses of autoantibodies in systemic lupus erythematosus, Sjogren's syndrome, and drug-induced autoimmunity. J Immunol. 1986 Oct 15;137(8):2528–2534. [PubMed] [Google Scholar]
  16. Salmi A., Reunanen M., Ilonen J., Panelius M. Intrathecal antibody synthesis to virus antigens in multiple sclerosis. Clin Exp Immunol. 1983 May;52(2):241–249. [PMC free article] [PubMed] [Google Scholar]
  17. Skvaril F. IgG subclasses in viral infections. Monogr Allergy. 1986;19:134–143. [PubMed] [Google Scholar]
  18. Vandvik B., Degré M. Measles virus antibodies in serum and cerebrospinal fluid in patients with multiple sclerosis and other neurological disorders, with special reference to measles antibody synthesis within the central nervous system. J Neurol Sci. 1975 Feb;24(2):201–219. doi: 10.1016/0022-510x(75)90233-6. [DOI] [PubMed] [Google Scholar]
  19. Vandvik B., Natvig J. B., Norrby E. IgG1 subclass restriction of oligoclonal measles virus-specific IgG antibodies in patients with subacute sclerosing panencephalitis and in a patient with multiple sclerosis. Scand J Immunol. 1977;6(6-7):651–657. doi: 10.1111/j.1365-3083.1977.tb02145.x. [DOI] [PubMed] [Google Scholar]
  20. Vandvik B., Norrby E., Nordal H. J., Degré M. Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. Scand J Immunol. 1976;5(8):979–992. doi: 10.1111/j.1365-3083.1976.tb03050.x. [DOI] [PubMed] [Google Scholar]
  21. Vartdal F., Vandvik B. Multiple sclerosis: subclasses of intrathecally synthesized IgG and measles and varicella zoster virus IgG antibodies. Clin Exp Immunol. 1983 Dec;54(3):641–647. [PMC free article] [PubMed] [Google Scholar]
  22. Waksman B. H., Reynolds W. E. Multiple sclerosis as a disease of immune regulation. Proc Soc Exp Biol Med. 1984 Mar;175(3):282–294. doi: 10.3181/00379727-175-41798. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES