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Tβ4 protein exerts cardioprotection in vivo. A, Retroinfusion of 15 mg recombinant Tβ4 reduces infarct size in a series of AAR sizes (B) similar to controls. C, Moreover, Tβ4 increases subendocardial segment shortening at rest and at atrial pacing (120 and 150 bpm) and (D) enhances dP/dtmax at rapid atrial pacing (#P<0.05 vs control; n=9). LV indicates left ventricle; SES, subendocardial segment shortening.
