Abstract
Two biotypes of Streptococcus bovis can be identified by laboratory testing and can be distinguished from the phenotypically similar organism Streptococcus salivarius. We assessed the clinical relevance of careful identification of these organisms in 68 patients with streptococcal bacteremia caused by these similar species. S. bovis was more likely to be clinically significant when isolated from blood (89%) than was S. salivarius (23%). There was a striking association between S. bovis I bacteremia and underlying endocarditis (94%) compared with that of S. bovis II bacteremia (18%). Bacteremia with S. bovis I was also highly correlated with an underlying colonic neoplasm (71% of patients overall, 100% of those with thorough colonic examinations) compared with bacteremia due to S. bovis II or S. salivarius (17% overall, 25% of patients with thorough colonic examinations). We conclude that careful identification of streptococcal bacteremic isolates as S. bovis biotype I provides clinically important information and should be more widely applied.
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Selected References
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- Broome C. V., Moellering R. C., Jr, Watson B. K. Clinical significance of Lancefield groups L-T streptococci isolated from blood and cerebrospinal fluid. J Infect Dis. 1976 Apr;133(4):382–392. doi: 10.1093/infdis/133.4.382. [DOI] [PubMed] [Google Scholar]
- Caputo G. M., Archer G. L., Calderwood S. B., DiNubile M. J., Karchmer A. W. Native valve endocarditis due to coagulase-negative staphylococci. Clinical and microbiologic features. Am J Med. 1987 Oct;83(4):619–625. doi: 10.1016/0002-9343(87)90889-8. [DOI] [PubMed] [Google Scholar]
- Facklam R. R. Recognition of group D streptococcal species of human origin by biochemical and physiological tests. Appl Microbiol. 1972 Jun;23(6):1131–1139. doi: 10.1128/am.23.6.1131-1139.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Facklam R. R., Rhoden D. L., Smith P. B. Evaluation of the Rapid Strep system for the identification of clinical isolates of Streptococcus species. J Clin Microbiol. 1984 Nov;20(5):894–898. doi: 10.1128/jcm.20.5.894-898.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Facklam R., Bosley G. S., Rhoden D., Franklin A. R., Weaver N., Schulman R. Comparative evaluation of the API 20S and AutoMicrobic gram-positive identification systems for non-beta-hemolytic streptococci and aerococci. J Clin Microbiol. 1985 Apr;21(4):535–541. doi: 10.1128/jcm.21.4.535-541.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoecker J. L., Pickering L. K., Groschel D., Kohl S. Streptococcus salivarius sepsis in children with malignancies. J Pediatr. 1978 Feb;92(2):337–338. doi: 10.1016/s0022-3476(78)80040-7. [DOI] [PubMed] [Google Scholar]
- Klein R. S., Catalano M. T., Edberg S. C., Casey J. I., Steigbigel N. H. Streptococcus bovis septicemia and carcinoma of the colon. Ann Intern Med. 1979 Oct;91(4):560–562. doi: 10.7326/0003-4819-91-4-560. [DOI] [PubMed] [Google Scholar]
- Klein R. S., Recco R. A., Catalano M. T., Edberg S. C., Casey J. I., Steigbigel N. H. Association of Streptococcus bovis with carcinoma of the colon. N Engl J Med. 1977 Oct 13;297(15):800–802. doi: 10.1056/NEJM197710132971503. [DOI] [PubMed] [Google Scholar]
- Klein R. S., Warman S. W., Knackmuhs G. G., Edberg S. C., Steigbigel N. H. Lack of association of Streptococcus bovis with noncolonic gastrointestinal carcinoma. Am J Gastroenterol. 1987 Jun;82(6):540–543. [PubMed] [Google Scholar]
- Murray H. W., Roberts R. B. Streptococcus bovis bacteremia and underlying gastrointestinal disease. Arch Intern Med. 1978 Jul;138(7):1097–1099. [PubMed] [Google Scholar]
- Parker M. T., Ball L. C. Streptococci and aerococci associated with systemic infection in man. J Med Microbiol. 1976 Aug;9(3):275–302. doi: 10.1099/00222615-9-3-275. [DOI] [PubMed] [Google Scholar]
- Reynolds J. G., Silva E., McCormack W. M. Association of Streptococcus bovis bacteremia with bowel disease. J Clin Microbiol. 1983 Apr;17(4):696–697. doi: 10.1128/jcm.17.4.696-697.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roses D. F., Richman H., Localio S. A. Bacterial endocarditis associated with colorectal carcinoma. Ann Surg. 1974 Feb;179(2):190–191. doi: 10.1097/00000658-197402000-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ruoff K. L., Ferraro M. J., Holden J., Kunz L. J. Identification of Streptococcus bovis and Streptococcus salivarius in clinical laboratories. J Clin Microbiol. 1984 Aug;20(2):223–226. doi: 10.1128/jcm.20.2.223-226.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]