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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Methods. 2008 Nov 17;47(4):304–307. doi: 10.1016/j.ymeth.2008.10.023

Fig. 1.

Fig. 1

Schematic of the MS-based protein footprinting method. The structures of the IN CCD and its complex with the LEDGF IBD are used for illustration, while the experiments were performed with full-length IN and LEDGF. In parallel experiments free IN and the complex are subjected to treatments by small chemical modifiers (M) and analyzed as described in the text.