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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Biomaterials. 2009 Jan 29;30(11):1989–2005. doi: 10.1016/j.biomaterials.2008.11.025

Figure 3.

Figure 3

Schematic of viral immune evasive secretions. a: Schematic of cytokine inhibition by viral proteins. Cowpox virus encodes for CrmA, preventing cleavage of pro IL-1β to IL-1β. b: The generation of vIL-10 from viruses activates JAK/STAT, p38 and MAP kinase pathways, producing carbon monoxide. It is believed that carbon monoxide is the agent that blocks transcription of pro-inflammatory cytokines. c: The complexation of a pro-inflammatory cytokine with a virally derived receptor homologue will prevent cytokine binding and activation of pro-inflammatory pathways in surrounding cells. d: Viruses incorporate host derived proteins like CD59 that will inhibit complementary response.