Abstract
Diffusion susceptibility tests with 30-micrograms cefadroxil disks and 30-micrograms cephalothin disks were evaluated. For both agents, the same zone size interpretive criteria were recommended (less than or equal to 14 mm for resistance and greater than or equal to 18 mm for susceptibility). Tests were performed with 904 bacterial isolates, and the data were examined to determine whether the two cephalosporins might be used interchangeably for purposes of in vitro susceptibility testing. When Haemophilus influenzae, Listeria monocytogenes, and methicillin-resistant staphylococci were evaluated, the two agents differed significantly. For testing other species, a cephalothin disk or cephalothin MIC could be used for predicting susceptibility or resistance to cefadroxil.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Barry A. L., Thornsberry C., Jones R. N., Fuchs P. C., Gavan T. L., Gerlach E. H. Reassessment of the "class" concept of disk susceptibility testing. Cephalothin disks versus minimal inhibitory concentrations with eleven cephalosporins. Am J Clin Pathol. 1978 Dec;70(6):909–913. doi: 10.1093/ajcp/70.6.909. [DOI] [PubMed] [Google Scholar]
- Buck R. E., Price K. E. Cefadroxil, a new broad-spectrum cephalosporin. Antimicrob Agents Chemother. 1977 Feb;11(2):324–330. doi: 10.1128/aac.11.2.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Casewell M. W., Bragman S. G. The in-vitro activity of cefadroxil, and the interpretation of disc-susceptibility testing. J Antimicrob Chemother. 1987 May;19(5):597–603. doi: 10.1093/jac/19.5.597. [DOI] [PubMed] [Google Scholar]
- Grimm H. Bakteriologische In-vitro-Untersuchungen mit Cefadroxil. Korrelation von Hemmhofdurchmesser und minimaler hemmkonzentration. Arzneimittelforschung. 1980;30(2):301–303. [PubMed] [Google Scholar]
- Jorgensen J. H., Redding J. S., Maher L. A., Howell A. W. Improved medium for antimicrobial susceptibility testing of Haemophilus influenzae. J Clin Microbiol. 1987 Nov;25(11):2105–2113. doi: 10.1128/jcm.25.11.2105-2113.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Leitner F., McGregor M. C., Pursiano T. A. Comparative antibacterial spectrum of cefadroxil. J Antimicrob Chemother. 1982 Sep;10 (Suppl B):1–9. doi: 10.1093/jac/10.suppl_b.1. [DOI] [PubMed] [Google Scholar]
- Preston D. A., Jones R. N., Barry A. L., Thornsberry C. Comparison of the antibacterial spectra of cephalexin and cefaclor with those of cephalothin and newer cephalosporins: reevaluation of the class representative concept of susceptibility testing. J Clin Microbiol. 1983 Jun;17(6):1156–1158. doi: 10.1128/jcm.17.6.1156-1158.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Quintiliani R. A review of the penetration of cefadroxil into human tissue. J Antimicrob Chemother. 1982 Sep;10 (Suppl B):33–38. doi: 10.1093/jac/10.suppl_b.33. [DOI] [PubMed] [Google Scholar]
- Santella P. J., Henness D. A review of the bioavailability of cefadroxil. J Antimicrob Chemother. 1982 Sep;10 (Suppl B):17–25. doi: 10.1093/jac/10.suppl_b.17. [DOI] [PubMed] [Google Scholar]