Table 1.
Plasma lipid transfer enzyme concentrations in lean and obese men and women
| Lean (n = 40) | Obese (n = 40) | Two-way ANOVA p-values | |||||
|---|---|---|---|---|---|---|---|
| Men | Women | Men | Women | obesity | sex | interaction | |
| n | 18 | 22 | 13 | 27 | |||
| Body mass index (kg/m2) | 22.6 ± 0.4 | 22.4 ± 0.3 | 34.5 ± 1.2 | 35.1 ± 0.7 | < 0.001 | 0.793 | 0.547 |
| Body fat (% body weight) | 14.1 ± 1.3 | 28.2 ± 0.8 | 33.9 ± 2.2 | 48.2 ± 1.1 | < 0.001 | < 0.001 | 0.929 |
| Abdominal fat (cm2) | 133 ± 28 | 166 ± 18 | 625 ± 66 | 561 ± 36 | < 0.001 | 0.692 | 0.221 |
| Intra-abdominal fat (% total) | 39 ± 6 | 23 ± 3 | 46 ± 3 | 25 ± 2 | 0.291 | 0.000 | 0.478 |
| Plasma glucose (mmol/l) | 4.98 ± 0.09 | 4.86 ± 0.04 | 5.25 ± 0.09 | 4.95 ± 0.06 | 0.012 | 0.003 | 0.202 |
| Plasma triglyceride (mmol/l) | 0.80 ± 0.04 | 0.67 ± 0.04 | 1.21 ± 0.06 | 1.14 ± 0.06 | < 0.001 | 0.072 | 0.596 |
| VLDL-triglyceride (mmol/l) | 0.54 ± 0.03 | 0.40 ± 0.03 | 0.89 ± 0.06 | 0.78 ± 0.05 | < 0.001 | 0.012 | 0.730 |
| HDL-cholesterol (mmol/l) | 0.91 ± 0.05 | 1.16 ± 0.05 | 0.79 ± 0.05 | 0.90 ± 0.04 | < 0.001 | 0.001 | 0.198 |
| LCAT (μg/ml) | 548 ± 20 | 513 ± 20 | 730 ± 39 | 654 ± 26 | < 0.001 | 0.041 | 0.446 |
| CETP (μg/ml) | 170 ± 7 | 175 ± 6 | 192 ± 8 | 215 ± 8 | < 0.001 | 0.085 | 0.248 |
| LPL (ng/ml) | 31 ± 2 | 40 ± 3 | 35 ± 3 | 48 ± 3 | 0.071 | 0.001 | 0.436 |
| HL (ng/ml) | 6.6 ± 0.8 | 6.8 ± 0.9 | 10.0 ± 1.1*† | 6.8 ± 0.6 | - | - | 0.048 |
Values are means ± SEM.
*
Significantly different from corresponding value in lean men (p = 0.018).
†
Significantly different from corresponding value in obese women (p = 0.009).
VLDL, very-low density lipoprotein; HDL, high-density lipoprotein; LCAT, lecithin-cholesterol acyl transferase; LPL, lipoprotein lipase; CETP, cholesterol-ester transfer protein; HL, hepatic lipase.