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. 1989 Aug;27(8):1870–1873. doi: 10.1128/jcm.27.8.1870-1873.1989

Seroepidemiology of Campylobacter pylori infection in various populations.

F Mégraud 1, M P Brassens-Rabbé 1, F Denis 1, A Belbouri 1, D Q Hoa 1
PMCID: PMC267687  PMID: 2549098

Abstract

Campylobacter pylori infection has been recognized as being strongly associated with chronic gastritis and duodenal ulceration, but the prevalence of C. pylori infection in a normal population is not known. A serological survey was conducted in four countries with different geographical and socioeconomic status, in a randomly chosen population as representative as possible, by using an enzyme-linked immunosorbent assay (ELISA) with a sonic extract of two strains as the antigen. The test had a specificity of 94% when 600 ELISA units was used as the threshold. In France, few children were infected before the age of 10 years. The prevalence then increased gradually to 36.7% in the sixth decade of life. This increasing prevalence of infection with age was also observed in Algeria, Vietnam, and the Ivory Coast but at a higher rate (80 to 90%). In Vietnam, as in France, few children were infected, whereas in Africa, C. pylori infection occurred earlier. The prevalence of infection did not differ with sex for a particular age group; it also did not differ with respect to gastric symptoms, smoking and drinking habits, or urban or rural residence when these potential risk factors were studied. The epidemiological data available on peptic ulcer disease in developing countries compared with developed countries led to the speculation that infection with C. pylori is not a sufficient condition to develop this disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bateson E. M. Duodenal ulcer--does it exist in Australia aborigines? Aust N Z J Med. 1976 Dec;6(6):545–547. doi: 10.1111/j.1445-5994.1976.tb03991.x. [DOI] [PubMed] [Google Scholar]
  2. Blaser M. J. Gastric Campylobacter-like organisms, gastritis, and peptic ulcer disease. Gastroenterology. 1987 Aug;93(2):371–383. doi: 10.1016/0016-5085(87)91028-6. [DOI] [PubMed] [Google Scholar]
  3. Booth L., Holdstock G., MacBride H., Hawtin P., Gibson J. R., Ireland A., Bamforth J., DuBoulay C. E., Lloyd R. S., Pearson A. D. Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy. J Clin Pathol. 1986 Feb;39(2):215–219. doi: 10.1136/jcp.39.2.215. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dwyer B., Kaldor J., Tee W., Marakowski E., Raios K. Antibody response to Campylobacter pylori in diverse ethnic groups. Scand J Infect Dis. 1988;20(3):349–350. doi: 10.3109/00365548809032465. [DOI] [PubMed] [Google Scholar]
  5. Dwyer B., Sun N. X., Kaldor J., Tee W., Lambert J., Luppino M., Flannery G. Antibody response to Campylobacter pylori in an ethnic group lacking peptic ulceration. Scand J Infect Dis. 1988;20(1):63–68. doi: 10.3109/00365548809117218. [DOI] [PubMed] [Google Scholar]
  6. Eastwood G. L., Reilly P. C., Jr Tropical peptic ulcer disease: an endoscopic study from rural Haiti. J Clin Gastroenterol. 1986 Jun;8(3 Pt 2):385–388. doi: 10.1097/00004836-198606002-00011. [DOI] [PubMed] [Google Scholar]
  7. Goodwin C. S., Blincow E., Peterson G., Sanderson C., Cheng W., Marshall B., Warren J. R., McCulloch R. Enzyme-linked immunosorbent assay for Campylobacter pyloridis: correlation with presence of C. pyloridis in the gastric mucosa. J Infect Dis. 1987 Mar;155(3):488–494. doi: 10.1093/infdis/155.3.488. [DOI] [PubMed] [Google Scholar]
  8. Graham D. Y., Klein P. D., Opekun A. R., Boutton T. W., Evans D. J., Jr, Evans D. G., Alpert L. C., Michaletz P. A., Yoshimura H. H., Adam E. Epidemiology of Campylobacter pylori infection: ethnic considerations. Scand J Gastroenterol Suppl. 1988;142:9–13. [PubMed] [Google Scholar]
  9. Hirschl A. M., Pletschette M., Hirschl M. H., Berger J., Stanek G., Rotter M. L. Comparison of different antigen preparations in an evaluation of the immune response to Campylobacter pylori. Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):570–575. doi: 10.1007/BF01962618. [DOI] [PubMed] [Google Scholar]
  10. Hugh T. B., Coleman M. J., McNamara M. E., Norman J. R., Howell C. Epidemiology of peptic ulcer in Australia. A study based on government statistics in four states. Med J Aust. 1984 Jul 21;141(2):81–85. [PubMed] [Google Scholar]
  11. Jones D. M., Eldridge J., Fox A. J., Sethi P., Whorwell P. J. Antibody to the gastric campylobacter-like organism ("Campylobacter pyloridis")--clinical correlations and distribution in the normal population. J Med Microbiol. 1986 Aug;22(1):57–62. doi: 10.1099/00222615-22-1-57. [DOI] [PubMed] [Google Scholar]
  12. Madanagopalan N., Balakumar K., Gajaraj A. J. Epidemiology of peptic ulcer disease in India. Indian J Gastroenterol. 1986 Oct;5 (Suppl):3–6. [PubMed] [Google Scholar]
  13. Megraud F., Bonnet F., Garnier M., Lamouliatte H. Characterization of "Campylobacter pyloridis" by culture, enzymatic profile, and protein content. J Clin Microbiol. 1985 Dec;22(6):1007–1010. doi: 10.1128/jcm.22.6.1007-1010.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Morris A., Nicholson G., Lloyd G., Haines D., Rogers A., Taylor D. Seroepidemiology of Campylobacter pyloridis. N Z Med J. 1986 Sep 10;99(809):657–659. [PubMed] [Google Scholar]
  15. Perez-Perez G. I., Blaser M. J. Conservation and diversity of Campylobacter pyloridis major antigens. Infect Immun. 1987 May;55(5):1256–1263. doi: 10.1128/iai.55.5.1256-1263.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Perez-Perez G. I., Dworkin B. M., Chodos J. E., Blaser M. J. Campylobacter pylori antibodies in humans. Ann Intern Med. 1988 Jul 1;109(1):11–17. doi: 10.7326/0003-4819-109-1-11. [DOI] [PubMed] [Google Scholar]
  17. Rathbone B. J., Wyatt J. I., Worsley B. W., Shires S. E., Trejdosiewicz L. K., Heatley R. V., Losowsky M. S. Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia. Gut. 1986 Jun;27(6):642–647. doi: 10.1136/gut.27.6.642. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rouvroy D., Bogaerts J., Nsengiumwa O., Omar M., Versailles L., Haot J. Campylobacter pylori, gastritis, and peptic ulcer disease in central Africa. Br Med J (Clin Res Ed) 1987 Nov 7;295(6607):1174–1174. doi: 10.1136/bmj.295.6607.1174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Tovey F. I., Tunstall M. Duodenal ulcer in black populations in Africa south of the Sahara. Gut. 1975 Jul;16(7):564–576. doi: 10.1136/gut.16.7.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Varis K. Epidemiology of gastritis. Scand J Gastroenterol Suppl. 1982;79:44–51. [PubMed] [Google Scholar]
  21. von Wulffen H., Grote H. J. Enzyme-linked immunosorbent assay for detection of immunoglobulin A and G antibodies to Campylobacter pylori. Eur J Clin Microbiol Infect Dis. 1988 Aug;7(4):559–565. doi: 10.1007/BF01962616. [DOI] [PubMed] [Google Scholar]

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