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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1990 May;28(5):926–929. doi: 10.1128/jcm.28.5.926-929.1990

Geographic distribution, frequency, and specimen source of Mycobacterium avium complex serotypes isolated from patients with acquired immunodeficiency syndrome.

M A Yakrus 1, R C Good 1
PMCID: PMC267838  PMID: 2351735

Abstract

Isolates of Mycobacterium avium complex from 727 patients with acquired immunodeficiency syndrome (AIDS) were submitted by medical centers across the United States to the Centers for Disease Control for serotyping. We were able to type 630 (87%) of these isolates by our seroagglutination procedure. Almost all typeable isolates were M. avium (serotypes 1 to 6 and 8 to 11). Blood was the major specimen source for both M. avium and the nontypeable isolates. M. intracellulare serotypes made up only 3% of all isolates from AIDS patients, with sputum being the major specimen source. More than 50% of the isolates originated from either New York or California, with serotype 4 being isolated most frequently in New York and serotype 8 appearing most frequently in California. AIDS patients in Los Angeles had a significantly higher isolation frequency for serotype 8 and a significantly lower one for serotype 4 in comparison with patients in either San Francisco or New York City.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baess I. Deoxyribonucleic acid relationships between different serovars of Mycobacterium avium, Mycobacterium intracellulare and Mycobacterium scrofulaceum. Acta Pathol Microbiol Immunol Scand B. 1983 Jun;91(3):201–203. doi: 10.1111/j.1699-0463.1983.tb00033.x. [DOI] [PubMed] [Google Scholar]
  2. Brennan P. J., Aspinall G. O., Shin J. E. Structure of the specific oligosaccharides from the glycopeptidolipid antigens of serovars in the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex. J Biol Chem. 1981 Jul 10;256(13):6817–6822. [PubMed] [Google Scholar]
  3. Brennan P. J., Goren M. B. Structural studies on the type-specific antigens and lipids of the mycobacterium avium. Mycobacterium intracellulare. Mycobacterium scrofulaceum serocomplex. Mycobacterium intracellulare serotype 9. J Biol Chem. 1979 May 25;254(10):4205–4211. [PubMed] [Google Scholar]
  4. Damsker B., Bottone E. J. Mycobacterium avium-Mycobacterium intracellulare from the intestinal tracts of patients with the acquired immunodeficiency syndrome: concepts regarding acquisition and pathogenesis. J Infect Dis. 1985 Jan;151(1):179–181. doi: 10.1093/infdis/151.1.179. [DOI] [PubMed] [Google Scholar]
  5. Good R. C. Opportunistic pathogens in the genus Mycobacterium. Annu Rev Microbiol. 1985;39:347–369. doi: 10.1146/annurev.mi.39.100185.002023. [DOI] [PubMed] [Google Scholar]
  6. Hawkins C. C., Gold J. W., Whimbey E., Kiehn T. E., Brannon P., Cammarata R., Brown A. E., Armstrong D. Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986 Aug;105(2):184–188. doi: 10.7326/0003-4819-105-2-184. [DOI] [PubMed] [Google Scholar]
  7. Horsburgh C. R., Jr, Cohn D. L., Roberts R. B., Masur H., Miller R. A., Tsang A. Y., Iseman M. D. Mycobacterium avium-M. intracellulare isolates from patients with or without acquired immunodeficiency syndrome. Antimicrob Agents Chemother. 1986 Dec;30(6):955–957. doi: 10.1128/aac.30.6.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kiehn T. E., Edwards F. F., Brannon P., Tsang A. Y., Maio M., Gold J. W., Whimbey E., Wong B., McClatchy J. K., Armstrong D. Infections caused by Mycobacterium avium complex in immunocompromised patients: diagnosis by blood culture and fecal examination, antimicrobial susceptibility tests, and morphological and seroagglutination characteristics. J Clin Microbiol. 1985 Feb;21(2):168–173. doi: 10.1128/jcm.21.2.168-173.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McClatchy J. K. The seroagglutination test in the study of nontuberculous mycobacteria. Rev Infect Dis. 1981 Sep-Oct;3(5):867–870. doi: 10.1093/clinids/3.5.867. [DOI] [PubMed] [Google Scholar]
  10. McNeil M., Tsang A. Y., Brennan P. J. Structure and antigenicity of the specific oligosaccharide hapten from the glycopeptidolipid antigen of Mycobacterium avium serotype 4, the dominant Mycobacterium isolated from patients with acquired immune deficiency syndrome. J Biol Chem. 1987 Feb 25;262(6):2630–2635. [PubMed] [Google Scholar]
  11. Meissner G., Anz W. Sources of Mycobacterium avium complex infection resulting in human diseases. Am Rev Respir Dis. 1977 Dec;116(6):1057–1064. doi: 10.1164/arrd.1977.116.6.1057. [DOI] [PubMed] [Google Scholar]
  12. Schaefer W. B. Serologic identification and classification of the atypical mycobacteria by their agglutination. Am Rev Respir Dis. 1965 Dec;92(6):85–93. doi: 10.1164/arrd.1965.92.6P2.85. [DOI] [PubMed] [Google Scholar]
  13. Stacey A. R. Isolation of Mycobacterium avium-intracellulare-scrofulaceum complex from faeces of patients with AIDS. Br Med J (Clin Res Ed) 1986 Nov 8;293(6556):1194–1194. doi: 10.1136/bmj.293.6556.1194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Wallace R. J., Jr, Musser J. M., Hull S. I., Silcox V. A., Steele L. C., Forrester G. D., Labidi A., Selander R. K. Diversity and sources of rapidly growing mycobacteria associated with infections following cardiac surgery. J Infect Dis. 1989 Apr;159(4):708–716. doi: 10.1093/infdis/159.4.708. [DOI] [PubMed] [Google Scholar]
  15. Young L. S. Mycobacterium avium complex infection. J Infect Dis. 1988 May;157(5):863–867. doi: 10.1093/infdis/157.5.863. [DOI] [PubMed] [Google Scholar]

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