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. 1990 Jun;28(6):1181–1184. doi: 10.1128/jcm.28.6.1181-1184.1990

Antibody to cytotoxin in infection by Helicobacter pylori.

R D Leunk 1, M A Ferguson 1, D R Morgan 1, D E Low 1, A E Simor 1
PMCID: PMC267901  PMID: 2380350

Abstract

Gastrointestinal disease and colonization by Helicobacter pylori were determined in 36 asymptomatic volunteers and 30 symptomatic individuals undergoing endoscopy and biopsy. Serum antibody immunoglobulin G (IgG) and IgA to H. pylori were measured by enzyme-linked immunosorbent assay. Serum antibody to a cytotoxin produced by H. pylori was detected with a neutralization assay. Serum IgG was 95% predictive of infection by H. pylori, and serum IgA was 88% predictive. Antibody to the cytotoxin was detected in 12 of 18 infected individuals. Antibody to the cytotoxin was a highly specific (96%), but not a very sensitive (67%), indicator of infection by H. pylori. The neutralization assay was 87% predictive of infection. These data confirm the diagnostic value of serum antibody to H. pylori for the detection of infection. The toxin-neutralizing activity of sera from individuals infected with H. pylori suggests that the cytotoxin is produced in vivo. It may therefore contribute to disease associated with H. pylori.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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