Abstract
The Directigen 1,2,3 Group A Strep Test (DGAST; BBL Microbiology Systems, Cockeysville, Md.) was compared with conventional culture methods for the detection of group A streptococci. Among 327 children, the DGAST has a sensitivity of 75.0%, a specificity of 99.1%, and positive and negative predictive values of 97.5 and 89.3%, respectively, as compared with 48-h culture results. The lower sensitivity (60.0%) in 322 adults was related to the low incidence of group A streptococcal pharyngitis in that population (7.8%). The positive and negative predictive values for adults were 93.8 and 96.7%, respectively. Only 3 of 327 (0.9%) pediatric and 2 of 322 (0.6%) adult specimens yielded uninterpretable results in the DGAST.
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Selected References
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- Berkowitz C. D., Anthony B. F., Kaplan E. L., Wolinsky E., Bisno A. L. Cooperative study of latex agglutination to identify group A streptococcal antigen on throat swabs in patients with acute pharyngitis. J Pediatr. 1985 Jul;107(1):89–92. doi: 10.1016/s0022-3476(85)80621-1. [DOI] [PubMed] [Google Scholar]
- Campos J. M., Charilaou C. C. Evaluation of Detect-A-Strep and the Culturette Ten-Minute Strep ID kits for detection of group A streptococcal antigen in oropharyngeal swabs from children. J Clin Microbiol. 1985 Aug;22(2):145–148. doi: 10.1128/jcm.22.2.145-148.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chang M. J., Mohla C. Ten-minute detection of group A streptococci in pediatric throat swabs. J Clin Microbiol. 1985 Feb;21(2):258–259. doi: 10.1128/jcm.21.2.258-259.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Facklam R. R. Specificity study of kits for detection of group A streptococci directly from throat swabs. J Clin Microbiol. 1987 Mar;25(3):504–508. doi: 10.1128/jcm.25.3.504-508.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gerber M. A. Culturing of throat swabs: end of an era? J Pediatr. 1985 Jul;107(1):85–88. doi: 10.1016/s0022-3476(85)80620-x. [DOI] [PubMed] [Google Scholar]
- Gerber M. A., Randolph M. F., Chanatry J., Wright L. L., DeMeo K. K., Anderson L. R. Antigen detection test for streptococcal pharyngitis: evaluation of sensitivity with respect to true infections. J Pediatr. 1986 May;108(5 Pt 1):654–658. doi: 10.1016/s0022-3476(86)81036-8. [DOI] [PubMed] [Google Scholar]
- Gerber M. A., Spadaccini L. J., Wright L. L., Deutsch L. Latex agglutination tests for rapid identification of group A streptococci directly from throat swabs. J Pediatr. 1984 Nov;105(5):702–705. doi: 10.1016/s0022-3476(84)80286-3. [DOI] [PubMed] [Google Scholar]
- Huck W., Reed B. D., French T., Mitchell R. S. Comparison of the Directigen 1-2-3 Group A Strep Test with culture for detection of group A beta-hemolytic streptococci. J Clin Microbiol. 1989 Aug;27(8):1715–1718. doi: 10.1128/jcm.27.8.1715-1718.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kellogg J. A., Manzella J. P. Detection of group A streptococci in the laboratory or physician's office. Culture vs antibody methods. JAMA. 1986 May 16;255(19):2638–2642. [PubMed] [Google Scholar]
- Kelly M. T., Smith J. A., Jaffer S., Pearce L., Clarke A. Outpatient evaluation of a rapid, direct test for detection of group A streptococci in throat swabs. Am J Clin Pathol. 1987 Apr;87(4):522–525. doi: 10.1093/ajcp/87.4.522. [DOI] [PubMed] [Google Scholar]
- McCusker J. J., McCoy E. L., Young C. L., Alamares R., Hirsch L. S. Comparison of Directigen Group A Strep Test with a traditional culture technique for detection of group A beta-hemolytic streptococci. J Clin Microbiol. 1984 Oct;20(4):824–825. doi: 10.1128/jcm.20.4.824-825.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller J. M., Phillips H. L., Graves R. K., Facklam R. R. Evaluation of the Directigen Group A Strep test kit. J Clin Microbiol. 1984 Nov;20(5):846–848. doi: 10.1128/jcm.20.5.846-848.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schwabe L. D., Small M. T., Randall E. L. Comparison of TestPack Strep A test kit with culture technique for detection of group A streptococci. J Clin Microbiol. 1987 Feb;25(2):309–311. doi: 10.1128/jcm.25.2.309-311.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]