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. Author manuscript; available in PMC: 2010 May 11.
Published in final edited form as: Vaccine. 2009 Mar 13;27(21):2760–2767. doi: 10.1016/j.vaccine.2009.03.003

Figure 5. Effect of a vhs mutation on d106 immunogenicity.

Figure 5

Mice were inoculated with 2×106 PFU of d106-gag or RJ1-gag virus, followed by two booster inoculations at week 3 and week 6. Splenocytes were collected at week 4 and week 7 for ELISPOT as described in Figure 4. Serum samples were collected at week 0, week 3, and week 6 prior to booster inoculation, and week 9 after booster. A. HIV gag-specific CD8+ T cell responses as measured by ELISPOT. B. HIV Gag antibody responses, and C. anti-HSV antibody responses induced by d106-gag and d106Δvhs-gag (RJ1-gag) recombinant viruses determined by ELISA. The results are shown as mean of OD405±standard deviation.