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. 1990 Dec;28(12):2850–2852. doi: 10.1128/jcm.28.12.2850-2852.1990

Hepatitis B virus replication within the human spleen.

A M Di Bisceglie 1, J H Hoofnagle 1
PMCID: PMC268294  PMID: 2280024

Abstract

Southern blot analysis of splenic DNA from three patients with chronic hepatitis B revealed the presence of replicative intermediate forms of viral DNA. Hepatitis B viral RNA was detected in splenic RNA from two cases. Thus, hepatitis B virus appears to replicate in the human spleen, although at a lower level than in the liver.

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Selected References

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