Skip to main content
. 2008 Nov 8;27(2):250–259. doi: 10.1016/j.vaccine.2008.10.055

Fig. 5.

Fig. 5

CD8+ T cells in mice vaccinated with insect cell-derived Id are required for tumor eradication and demonstrate enhanced effector function. (A) BV glutaraldehyde Id-KLH elicits greater CTL activity than Hyb glutaraldehyde Id-KLH. Mice were given two bi-weekly vaccinations, after which CTLs from the spleen and lymph nodes were tested for their ability to lyse A20 lymphoma cells at an E:T ratio of 10:1. (B) Dependence of vaccine efficacy on CD8+ T cells. BALB/c mice were pre-depleted of CD4+ or CD8+ T cells, inoculated s.c. with A20 tumor and 4 days later given three weekly vaccinations of BV glutaraldehyde Id-KLH plus GM-CSF, and followed for survival.