Abstract
To develop a model system of herpes simplex labialis which would enable the study of patients before lesion onset, five patients were exposed to various doses of UV light from a sunlamp at their usual site of lesions. Six of 10 treatments resulted in the development of herpes labialis. Three of four treatments with the highest exposure levels led to large, vesicular, virus culture-positive sores. Side effects from sunlamp exposure were minimal.
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- Bader C., Crumpacker C. S., Schnipper L. E., Ransil B., Clark J. E., Arndt K., Freedberg I. M. The natural history of recurrent facial-oral infection with herpes simplex virus. J Infect Dis. 1978 Dec;138(6):897–905. doi: 10.1093/infdis/138.6.897. [DOI] [PubMed] [Google Scholar]
- Douglas R. G., Jr, Couch R. B. A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans. J Immunol. 1970 Feb;104(2):289–295. [PubMed] [Google Scholar]
- Greenberg M. S., Brightman V. J., Ship I. I. Clinical and laboratory differentiation of recurrent intraoral herpes simplex virus infections following fever. J Dent Res. 1969 May-Jun;48(3):385–391. doi: 10.1177/00220345690480031001. [DOI] [PubMed] [Google Scholar]
- Hill T. J., Blyth W. A. An alternative theory of herpes-simplex recurrence and a possible role for prostaglandins. Lancet. 1976 Feb 21;1(7956):397–399. doi: 10.1016/s0140-6736(76)90220-8. [DOI] [PubMed] [Google Scholar]
- Hill T. J., Field H. J., Blyth W. A. Acute and recurrent infection with herpes simplex virus in the mouse: a model for studying latency and recurrent disease. J Gen Virol. 1975 Sep;28(3):341–353. doi: 10.1099/0022-1317-28-3-341. [DOI] [PubMed] [Google Scholar]
- Pazin G. J., Ho M., Jannetta P. J. Reactivation of herpes simplex virus after decompression of the trigeminal nerve root. J Infect Dis. 1978 Sep;138(3):405–409. doi: 10.1093/infdis/138.3.405. [DOI] [PubMed] [Google Scholar]
- Spruance S. L., Crumpacker C. S., Schnipper L. E., Kern E. R., Marlowe S., Arndt K. A., Overall J. C., Jr Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir. Antimicrob Agents Chemother. 1984 May;25(5):553–555. doi: 10.1128/aac.25.5.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spruance S. L., Overall J. C., Jr, Kern E. R., Krueger G. G., Pliam V., Miller W. The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. N Engl J Med. 1977 Jul 14;297(2):69–75. doi: 10.1056/NEJM197707142970201. [DOI] [PubMed] [Google Scholar]
- Spruance S. L. Pathogenesis of herpes simplex labialis: excretion of virus in the oral cavity. J Clin Microbiol. 1984 May;19(5):675–679. doi: 10.1128/jcm.19.5.675-679.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Spruance S. L., Wenerstrom G. Pathogenesis of recurrent herpes simplex labialis. IV. Maturation of lesions within 8 hours after onset and implications for antiviral treatment. Oral Surg Oral Med Oral Pathol. 1984 Dec;58(6):667–671. doi: 10.1016/0030-4220(84)90031-8. [DOI] [PubMed] [Google Scholar]
- Stanberry L. R., Kern E. R., Richards J. T., Abbott T. M., Overall J. C., Jr Genital herpes in guinea pigs: pathogenesis of the primary infection and description of recurrent disease. J Infect Dis. 1982 Sep;146(3):397–404. doi: 10.1093/infdis/146.3.397. [DOI] [PubMed] [Google Scholar]
- TANKERSLEY R. W., Jr AMINO ACID REQUIREMENTS OF HERPES SIMPLEX VIRUS IN HUMAN CELLS. J Bacteriol. 1964 Mar;87:609–613. doi: 10.1128/jb.87.3.609-613.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wheeler C. E., Jr Pathogenesis of recurrent herpes simplex infections. J Invest Dermatol. 1975 Oct;65(4):341–346. doi: 10.1111/1523-1747.ep12607603. [DOI] [PubMed] [Google Scholar]