Table 4.

 Estimates of preventive effect of taking one or more blood pressure lowering drugs on coronary heart disease (CHD) events and stroke according to pretreatment diastolic blood pressure, age, number of drugs, and dose (as multiple of standard³³)

Pretreatment diastolic blood pressure (mm Hg)	Estimated reduction in diastolic blood pressure (mm Hg)	Relative risk of CHD events by age (years)						Relative risk of stroke by age (years)
		40-49	50-59	60-69	70-79	80-89		40-49	50-59	60-69	70-79	80-89
One drug half standard dose:
110	5.5	0.66	0.70	0.73	0.77	0.82		0.56	0.55	0.61	0.67	0.78
105	5	0.68	0.72	0.75	0.79	0.84		0.59	0.58	0.63	0.69	0.79
100	4.6	0.71	0.74	0.77	0.80	0.85		0.62	0.61	0.66	0.71	0.81
95	4.1	0.73	0.76	0.79	0.82	0.86		0.65	0.64	0.68	0.74	0.83
90	3.7	0.76	0.79	0.81	0.84	0.88		0.68	0.67	0.71	0.76	0.84
85	3.3	0.78	0.81	0.83	0.86	0.89		0.71	0.70	0.74	0.79	0.86
80	2.8	0.81	0.83	0.85	0.87	0.90		0.74	0.74	0.77	0.81	0.88
75	2.4	0.84	0.86	0.87	0.89	0.92		0.78	0.77	0.80	0.84	0.90
One drug standard dose:
110	6.9	0.59	0.64	0.67	0.72	0.78		0.48	0.47	0.53	0.60	0.73
105	6.4	0.62	0.66	0.69	0.74	0.80		0.51	0.50	0.56	0.63	0.74
100	5.8	0.64	0.68	0.71	0.76	0.81		0.54	0.53	0.59	0.65	0.76
95	5.3	0.67	0.71	0.74	0.78	0.83		0.57	0.57	0.62	0.68	0.78
90	4.7	0.70	0.73	0.76	0.80	0.84		0.61	0.60	0.65	0.71	0.80
85	4.2	0.73	0.76	0.78	0.82	0.86		0.64	0.64	0.68	0.74	0.82
80	3.6	0.76	0.79	0.81	0.84	0.88		0.68	0.68	0.72	0.77	0.85
75	3.1	0.79	0.82	0.84	0.86	0.90		0.72	0.72	0.75	0.80	0.87
Two drugs half standard dose:
110	10.8	0.44	0.49	0.53	0.60	0.68		0.32	0.31	0.37	0.45	0.61
105	9.9	0.47	0.52	0.56	0.62	0.70		0.35	0.34	0.40	0.48	0.63
100	9.1	0.50	0.55	0.59	0.65	0.72		0.39	0.38	0.44	0.51	0.66
95	8.2	0.54	0.59	0.62	0.68	0.75		0.42	0.41	0.47	0.55	0.69
90	7.3	0.58	0.62	0.65	0.71	0.77		0.46	0.45	0.51	0.59	0.71
85	6.4	0.62	0.66	0.69	0.74	0.80		0.51	0.50	0.56	0.62	0.74
80	5.5	0.66	0.70	0.73	0.77	0.82		0.56	0.55	0.60	0.67	0.77
75	4.7	0.70	0.74	0.76	0.80	0.85		0.61	0.60	0.65	0.71	0.81
Two drugs standard dose:
110	13.1	0.37	0.42	0.49	0.53	0.63		0.25	0.24	0.30	0.38	0.55
105	12.1	0.40	0.45	0.50	0.56	0.65		0.28	0.27	0.33	0.41	0.57
100	11.0	0.44	0.49	0.53	0.59	0.67		0.31	0.30	0.36	0.45	0.60
95	10.0	0.47	0.52	0.56	0.62	0.70		0.35	0.34	0.40	0.48	0.63
90	8.9	0.51	0.56	0.60	0.65	0.73		0.39	0.38	0.44	0.52	0.66
85	7.9	0.55	0.60	0.63	0.69	0.75		0.44	0.43	0.48	0.56	0.69
80	6.9	0.60	0.64	0.67	0.72	0.78		0.49	0.48	0.53	0.60	0.73
75	5.8	0.64	0.68	0.71	0.76	0.81		0.54	0.53	0.59	0.65	0.76
Three drugs half standard dose:
110	16.0	0.30	0.35	0.40	0.47	0.57		0.19	0.18	0.23	0.31	0.48
105	14.7	0.33	0.38	0.43	0.50	0.59		0.21	0.21	0.26	0.34	0.51
100	13.3	0.37	0.42	0.46	0.53	0.62		0.25	0.24	0.29	0.38	0.54
95	12.0	0.40	0.46	0.50	0.56	0.65		0.28	0.27	0.33	0.41	0.57
90	10.7	0.45	0.50	0.54	0.60	0.68		0.33	0.32	0.38	0.46	0.61
85	9.4	0.49	0.54	0.58	0.64	0.72		0.37	0.36	0.42	0.50	0.65
80	8.1	0.54	0.59	0.63	0.68	0.75		0.43	0.42	0.48	0.55	0.69
75	6.7	0.60	0.64	0.68	0.72	0.79		0.49	0.48	0.54	0.61	0.73
Three drugs standard dose:
110	18.6	0.25	0.30	0.34	0.41	0.52		0.14	0.13	0.18	0.26	0.42
105	17.1	0.27	0.33	0.37	0.44	0.54		0.17	0.16	0.21	0.28	0.45
100	15.6	0.31	0.36	0.40	0.47	0.57		0.19	0.19	0.24	0.32	0.49
95	14.2	0.34	0.40	0.44	0.51	0.60		0.23	0.22	0.27	0.35	0.52
90	12.7	0.38	0.44	0.48	0.55	0.64		0.26	0.25	0.31	0.39	0.56
85	11.2	0.43	0.48	0.52	0.59	0.67		0.31	0.30	0.36	0.44	0.60
80	9.7	0.48	0.53	0.57	0.63	0.71		0.36	0.35	0.41	0.49	0.64
75	8.3	0.54	0.58	0.62	0.67	0.74		0.42	0.41	0.47	0.55	0.68

This table is a numerical expansion of figure 6 (diastolic blood pressure). Estimates calculated using a two stage procedure in which the effect of drug treatment in reducing diastolic blood pressure was first estimated,³² then the effect of this blood pressure reduction on disease risk.²⁵

*See Methods (section headed “Predicting the trial results.”)