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. 2009 Feb 6;136(5):855–864. doi: 10.1242/dev.028605

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Fig. 4. — Genetic interaction between Twist1 and EphA4. Heads of wild-type, Twist1^+/- and Twist1^+/-; EphA4^+/- embryos were examined for the expression of ALP and the osteoblast determinant, Runx2. ALP was assessed by histochemistry, Runx2 by immunostaining. Skulls of P21 animals were stained with Alizarin Red (J-L). Note progressive loss of ALP-free zone of coronal suture with reduction of Twist1 and EphA4 dosage (A-C). Also note increased staining of Runx2 and ALP in sections of heads at E14.5 (D-I) and increased coronal suture fusion in skulls of P21 mice (J-L). cs, coronal suture; fb, frontal bone; pb, parietal bone; ss, sagittal suture.