Abstract
This report presents results from a sample survey designed to investigate the possible role of Cryptosporidium spp. in childhood diarrhea in a developing country, Liberia, West Africa. During the four months of January to April 1983, a house-to-house study was carried out in two geographically and socially different communities--an urban slum and three rural villages. Stool samples from 374 children, aged 6 to 59 months, were tested for Cryptosporidium spp. Among the children with diarrhea 8.4% were Cryptosporidium spp. positive compared with a prevalence rate of 5.9% in asymptomatic children. Of the children living in a household with a Cryptosporidium spp.-positive index child, 8.6% had a positive stool sample. Of all children attending a clinic because of diarrhea, 14.6% were Cryptosporidium spp. positive. Cryptosporidiosis was more frequent in younger children; 24 of the total of 29 positive cases (83%) were below 2.5 years old. Actual or previous bottle feeding (formula) was a risk factor, particularly in children below 18 months old. Of the bottle-fed children, 28% were Cryptosporidium spp. positive versus 9.1% of children never bottle fed. Crowding is another possible risk factor. The prevalence of cryptosporidiosis was 13.5% in big urban households with more than 10 children, whereas the prevalence in the small urban households was 6.1%. Ethnic and religious differences were particularly evident in the rural area. No Muslim households had cryptosporidiosis, whereas the prevalence in non-Muslim tribes was 9%. The general belief that cryptosporidiosis is primarily a zoonosis is questioned in this study, partly because many carriers and asymptomatic household contacts were found.
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- Allen A. V., Ridley D. S. Further observations on the formol-ether concentration technique for faecal parasites. J Clin Pathol. 1970 Sep;23(6):545–546. doi: 10.1136/jcp.23.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bogaerts J., Lepage P., Rouvroy D., Vandepitte J. Cryptosporidium spp., a frequent cause of diarrhea in Central Africa. J Clin Microbiol. 1984 Nov;20(5):874–876. doi: 10.1128/jcm.20.5.874-876.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Casemore D. P., Jackson F. B. Hypothesis: cryptosporidiosis in human beings is not primarily a zoonosis. J Infect. 1984 Sep;9(2):153–156. doi: 10.1016/s0163-4453(84)91117-4. [DOI] [PubMed] [Google Scholar]
- Current W. L., Reese N. C., Ernst J. V., Bailey W. S., Heyman M. B., Weinstein W. M. Human cryptosporidiosis in immunocompetent and immunodeficient persons. Studies of an outbreak and experimental transmission. N Engl J Med. 1983 May 26;308(21):1252–1257. doi: 10.1056/NEJM198305263082102. [DOI] [PubMed] [Google Scholar]
- Figueroa G., Troncoso M., Araya M., Espinoza J., Brunser O. Enteropathogen carriage by healthy individuals living in an area with poor sanitation. J Hyg (Lond) 1983 Dec;91(3):499–507. doi: 10.1017/s002217240006054x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Garcia L. S., Bruckner D. A., Brewer T. C., Shimizu R. Y. Techniques for the recovery and identification of Cryptosporidium oocysts from stool specimens. J Clin Microbiol. 1983 Jul;18(1):185–190. doi: 10.1128/jcm.18.1.185-190.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hart C. A., Baxby D., Blundell N. Gastro-enteritis due to Cryptosporidium: a prospective survey in a children's hospital. J Infect. 1984 Nov;9(3):264–270. doi: 10.1016/s0163-4453(84)90574-7. [DOI] [PubMed] [Google Scholar]
- Henriksen S. A., Pohlenz J. F. Staining of cryptosporidia by a modified Ziehl-Neelsen technique. Acta Vet Scand. 1981;22(3-4):594–596. doi: 10.1186/BF03548684. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ma P., Soave R. Three-step stool examination for cryptosporidiosis in 10 homosexual men with protracted watery diarrhea. J Infect Dis. 1983 May;147(5):824–828. doi: 10.1093/infdis/147.5.824. [DOI] [PubMed] [Google Scholar]
- Malebranche R., Arnoux E., Guérin J. M., Pierre G. D., Laroche A. C., Péan-Guichard C., Elie R., Morisset P. H., Spira T., Mandeville R. Acquired immunodeficiency syndrome with severe gastrointestinal manifestations in Haiti. Lancet. 1983 Oct 15;2(8355):873–878. doi: 10.1016/s0140-6736(83)90868-1. [DOI] [PubMed] [Google Scholar]
- Mata L., Bolaños H., Pizarro D., Vives M. Cryptosporidiosis in children from some highland Costa Rican rural and urban areas. Am J Trop Med Hyg. 1984 Jan;33(1):24–29. doi: 10.4269/ajtmh.1984.33.24. [DOI] [PubMed] [Google Scholar]
- Navin T. R., Juranek D. D. Cryptosporidiosis: clinical, epidemiologic, and parasitologic review. Rev Infect Dis. 1984 May-Jun;6(3):313–327. doi: 10.1093/clinids/6.3.313. [DOI] [PubMed] [Google Scholar]
- Nime F. A., Burek J. D., Page D. L., Holscher M. A., Yardley J. H. Acute enterocolitis in a human being infected with the protozoan Cryptosporidium. Gastroenterology. 1976 Apr;70(4):592–598. [PubMed] [Google Scholar]
- Pitlik S. D., Fainstein V., Garza D., Guarda L., Bolivar R., Rios A., Hopfer R. L., Mansell P. A. Human cryptosporidiosis: spectrum of disease. Report of six cases and review of the literature. Arch Intern Med. 1983 Dec;143(12):2269–2275. doi: 10.1001/archinte.1983.00350120059015. [DOI] [PubMed] [Google Scholar]
- Rohde J. E. Selective primary health care: strategies for control of disease in the developing world. XV. Acute diarrhea. Rev Infect Dis. 1984 Nov-Dec;6(6):840–854. doi: 10.1093/clinids/6.6.840. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Skirrow M. B. Campylobacter enteritis: a "new" disease. Br Med J. 1977 Jul 2;2(6078):9–11. doi: 10.1136/bmj.2.6078.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Snyder J. D., Merson M. H. The magnitude of the global problem of acute diarrhoeal disease: a review of active surveillance data. Bull World Health Organ. 1982;60(4):605–613. [PMC free article] [PubMed] [Google Scholar]
- Stemmermann G. N., Hayashi T., Glober G. A., Oishi N., Frankel R. I. Cryptosporidiosis. Report of a fatal case complicated by disseminated toxoplasmosis. Am J Med. 1980 Oct;69(4):637–642. doi: 10.1016/0002-9343(80)90481-7. [DOI] [PubMed] [Google Scholar]
- Tzipori S., Smith M., Birch C., Barnes G., Bishop R. Cryptosporidiosis in hospital patients with gastroenteritis. Am J Trop Med Hyg. 1983 Sep;32(5):931–934. doi: 10.4269/ajtmh.1983.32.931. [DOI] [PubMed] [Google Scholar]