Abstract
Standardized broth microdilution and disk diffusion susceptibility tests for pefloxacin were performed on 585 clinical isolates. The 5-micrograms pefloxacin disk is recommended, and the following breakpoints are proposed: susceptible, greater than or equal to 19 mm (MIC, less than or equal to 2.0 micrograms/ml); resistant, less than or equal to 15 mm (MIC, greater than 4.0 micrograms/ml); and intermediate, 16 to 18 mm.
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- Clarke A. M., Zemcov S. J., Campbell M. E. In-vitro activity of pefloxacin compared to enoxacin, norfloxacin, gentamicin and new beta-lactams. J Antimicrob Chemother. 1985 Jan;15(1):39–44. doi: 10.1093/jac/15.1.39. [DOI] [PubMed] [Google Scholar]
- Jones R. N., Barry A. L. Norfloxacin (MK-0366, AM-715): in vitro activity and cross-resistance with other organic acids including quality control limits for disk diffusion testing. Diagn Microbiol Infect Dis. 1983 Jun;1(2):165–172. doi: 10.1016/0732-8893(83)90047-0. [DOI] [PubMed] [Google Scholar]
- Ligtvoet E. E., Wickerhoff-Minoggio T. In-vitro activity of pefloxacin compared with six other quinolones. J Antimicrob Chemother. 1985 Oct;16(4):485–490. doi: 10.1093/jac/16.4.485. [DOI] [PubMed] [Google Scholar]
- Montay G., Goueffon Y., Roquet F. Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans. Antimicrob Agents Chemother. 1984 Apr;25(4):463–472. doi: 10.1128/aac.25.4.463. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wolff M., Regnier B., Daldoss C., Nkam M., Vachon F. Penetration of pefloxacin into cerebrospinal fluid of patients with meningitis. Antimicrob Agents Chemother. 1984 Sep;26(3):289–291. doi: 10.1128/aac.26.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]