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. 1986 Oct;24(4):573–580. doi: 10.1128/jcm.24.4.573-580.1986

Demonstration of antigenic variation among rabies virus isolates by using monoclonal antibodies to nucleocapsid proteins.

J S Smith, F L Reid-Sanden, L F Roumillat, C Trimarchi, K Clark, G M Baer, W G Winkler
PMCID: PMC268974  PMID: 2429983

Abstract

Rabies virus isolates from terrestrial animals in six areas of the United States were examined with a panel of monoclonal antibodies to nucleocapsid proteins. Characteristic differences in immunofluorescence reactions permitted the formation of four antigenically distinct reaction groups from the 231 isolates tested. The geographic distribution of these groups corresponded well with separate rabies enzootic areas recognized by surveillance of sylvatic rabies in the United States. Distinctive reaction patterns were also identified for viral proteins from four infected bat species, and identical patterns were found in eight isolated cases of rabies in terrestrial animals. These findings suggest that monoclonal antibodies can be used to study the prevalence, distribution, and transmission of rabies among wildlife species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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