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. 1986 Nov;24(5):775–778. doi: 10.1128/jcm.24.5.775-778.1986

Antibodies to basement membrane protein nidogen in Chagas' disease and American cutaneous leishmaniasis.

J L Avila, M Rojas, G Velazquez-Avila, H von der Mark, R Timpl
PMCID: PMC269027  PMID: 2429987

Abstract

About 50 to 70% of sera from patients with American cutaneous leishmaniasis and chronic Chagas' disease possessed antibodies which reacted in enzyme and radioimmunoassays with nidogen obtained from a tumor basement membrane. The antibodies were of the immunoglobulin M and G classes in acute American cutaneous leishmaniasis but mainly of the immunoglobulin G class in chronic Chagas' disease. Similar antibodies could not be detected in patients suffering from a variety of other infectious or inflammatory diseases when compared with healthy control groups. Inhibition and immunoadsorption studies indicated a close relationship of epitopes recognized by patients' antibodies on nidogen and on another basement membrane protein, laminin. Since rabbit antisera to both proteins do not cross-react, a special nature of the epitopes involved in the reaction with patient sera is suggested. Similar epitopes may exist on various forms of Leishmania or Trypanosoma protozoa.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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