Table I.
Statistical analysis of tumor development in B6129 Wnt-1 mice
| Sex | Genotype | n | Breast cancer ratea | P-valuebc | Other cause ratea | P-valueb |
| Intact female | p27−/− | 10 | 3.3 | 0.68 | 0.4 | |
| p27+/− | 15 | 3.5 | 0.97 | 0.0 | ||
| p27+/+ | 14 | 2.9 | 0.48, 0.44 | 0.0 | 0.20 | |
| Male | p27−/− | 21 | 1.0 | 0.82 | 1.1 | |
| p27+/− | 36 | 0.9 | 0.56 | 0.9 | ||
| p27+/+ | 19 | 0.9 | 0.58, 0.98 | 0.6 | 0.0005 | |
| OVX female | p27−/− | 20 | 2.0 | 0.44 | 3.0 | |
| p27+/− | 31 | 3.8 | 0.27 | 0.6 | ||
| p27+/+ | 25 | 3.4 | 0.25, 0.93 | 0.6 | 0.0001 |
OVX: ovariectomized and implanted with pellets of estrogen and P.
a
Events per 100 weeks of observation.
b
From Cox regression.
c
The first line P-value is the overall test of equality. The second line is the test of p27+/− versus p27−/−. The third line lists the tests of p27+/+ versus p27−/− and p27+/+ versus p27+/−.