Abstract
The acquired immunodeficiency syndrome-related complex was identified in a mother and one of her nonidentical twins. Generalized lymphadenopathy was first noted in the infant at age 17 months, and that of the mother was incidentally discovered 6 months later. The father, who had had homosexual contacts before the conception of the twins, appeared to be in good health. No one in the family had constitutional symptoms or showed signs of opportunistic infection. Both parents and the patient had hypergammaglobulinemia, low T-helper-to-suppressor-cell ratio, and positive serum antibody to human immunodeficiency virus. Attempts to isolate the virus from all family members were unsuccessful. The twin brother was in good health with a normal immunologic profile and negative antibody to human immunodeficiency virus.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ammann A. J. The acquired immunodeficiency syndrome in infants and children. Ann Intern Med. 1985 Nov;103(5):734–737. doi: 10.7326/0003-4819-103-5-734. [DOI] [PubMed] [Google Scholar]
- Cowan M. J., Hellmann D., Chudwin D., Wara D. W., Chang R. S., Ammann A. J. Maternal transmission of acquired immune deficiency syndrome. Pediatrics. 1984 Mar;73(3):382–386. [PubMed] [Google Scholar]
- Friedland G. H., Saltzman B. R., Rogers M. F., Kahl P. A., Lesser M. L., Mayers M. M., Klein R. S. Lack of transmission of HTLV-III/LAV infection to household contacts of patients with AIDS or AIDS-related complex with oral candidiasis. N Engl J Med. 1986 Feb 6;314(6):344–349. doi: 10.1056/NEJM198602063140604. [DOI] [PubMed] [Google Scholar]
- Gallo R. C., Salahuddin S. Z., Popovic M., Shearer G. M., Kaplan M., Haynes B. F., Palker T. J., Redfield R., Oleske J., Safai B. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984 May 4;224(4648):500–503. doi: 10.1126/science.6200936. [DOI] [PubMed] [Google Scholar]
- Jovaisas E., Koch M. A., Schäfer A., Stauber M., Löwenthal D. LAV/HTLV-III in 20-week fetus. Lancet. 1985 Nov 16;2(8464):1129–1129. doi: 10.1016/s0140-6736(85)90720-2. [DOI] [PubMed] [Google Scholar]
- Klein J. O., Buckland D., Finland M. Colonization of newborn infants by mycoplasmas. N Engl J Med. 1969 May 8;280(19):1025–1030. doi: 10.1056/NEJM196905082801901. [DOI] [PubMed] [Google Scholar]
- Lapointe N., Michaud J., Pekovic D., Chausseau J. P., Dupuy J. M. Transplacental transmission of HTLV-III virus. N Engl J Med. 1985 May 16;312(20):1325–1326. doi: 10.1056/NEJM198505163122012. [DOI] [PubMed] [Google Scholar]
- Menez-Bautista R., Fikrig S. M., Pahwa S., Sarangadharan M. G., Stoneburner R. L. Monozygotic twins discordant for the acquired immunodeficiency syndrome. Am J Dis Child. 1986 Jul;140(7):678–679. doi: 10.1001/archpedi.1986.02140210076029. [DOI] [PubMed] [Google Scholar]
- Montagnier L. Lymphadenopathy-associated virus: from molecular biology to pathogenicity. Ann Intern Med. 1985 Nov;103(5):689–693. doi: 10.7326/0003-4819-103-5-689. [DOI] [PubMed] [Google Scholar]
- Oleske J., Minnefor A., Cooper R., Jr, Thomas K., dela Cruz A., Ahdieh H., Guerrero I., Joshi V. V., Desposito F. Immune deficiency syndrome in children. JAMA. 1983 May 6;249(17):2345–2349. [PubMed] [Google Scholar]
- Pahwa S., Kaplan M., Fikrig S., Pahwa R., Sarngadharan M. G., Popovic M., Gallo R. C. Spectrum of human T-cell lymphotropic virus type III infection in children. Recognition of symptomatic, asymptomatic, and seronegative patients. JAMA. 1986 May 2;255(17):2299–2305. [PubMed] [Google Scholar]
- Peterman T. A., Jaffe H. W., Feorino P. M., Getchell J. P., Warfield D. T., Haverkos H. W., Stoneburner R. L., Curran J. W. Transfusion-associated acquired immunodeficiency syndrome in the United States. JAMA. 1985 Nov 22;254(20):2913–2917. [PubMed] [Google Scholar]
- Salahuddin S. Z., Groopman J. E., Markham P. D., Sarngadharan M. G., Redfield R. R., McLane M. F., Essex M., Sliski A., Gallo R. C. HTLV-III in symptom-free seronegative persons. Lancet. 1984 Dec 22;2(8417-8418):1418–1420. doi: 10.1016/s0140-6736(84)91619-2. [DOI] [PubMed] [Google Scholar]
- Sarngadharan M. G., Popovic M., Bruch L., Schüpbach J., Gallo R. C. Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science. 1984 May 4;224(4648):506–508. doi: 10.1126/science.6324345. [DOI] [PubMed] [Google Scholar]
- Scott G. B., Buck B. E., Leterman J. G., Bloom F. L., Parks W. P. Acquired immunodeficiency syndrome in infants. N Engl J Med. 1984 Jan 12;310(2):76–81. doi: 10.1056/NEJM198401123100202. [DOI] [PubMed] [Google Scholar]
- Selwyn P. A. AIDS: what is now known. I. History and immunovirology. Hosp Pract (Off Ed) 1986 May 15;21(5):67-76, 81-2. [PubMed] [Google Scholar]
- Selwyn P. A. AIDS: what is now known. II. Epidemiology. Hosp Pract (Off Ed) 1986 Jun 15;21(6):127-9, 133-4, 139 passim. [PubMed] [Google Scholar]
- Shannon K. M., Ammann A. J. Acquired immune deficiency syndrome in childhood. J Pediatr. 1985 Feb;106(2):332–342. doi: 10.1016/s0022-3476(85)80320-6. [DOI] [PubMed] [Google Scholar]
- Vilmer E., Fischer A., Griscelli C., Barre-Sinoussi F., Vie V., Chermann J. C., Montagnier L., Rouzioux C., Brun-Vezinet F., Rosenbaum W. Possible transmission of a human lymphotropic retrovirus (LAV) from mother to infant with AIDS. Lancet. 1984 Jul 28;2(8396):229–230. doi: 10.1016/s0140-6736(84)90519-1. [DOI] [PubMed] [Google Scholar]
- Weber J. N., Wadsworth J., Rogers L. A., Moshtael O., Scott K., McManus T., Berrie E., Jeffries D. J., Harris J. R., Pinching A. J. Three-year prospective study of HTLV-III/LAV infection in homosexual men. Lancet. 1986 May 24;1(8491):1179–1182. doi: 10.1016/s0140-6736(86)91160-8. [DOI] [PubMed] [Google Scholar]
- Ziegler J. B., Cooper D. A., Johnson R. O., Gold J. Postnatal transmission of AIDS-associated retrovirus from mother to infant. Lancet. 1985 Apr 20;1(8434):896–898. doi: 10.1016/s0140-6736(85)91673-3. [DOI] [PubMed] [Google Scholar]
