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. 1987 Aug;25(8):1564–1566. doi: 10.1128/jcm.25.8.1564-1566.1987

Seasonal prevalence of Borrelia burgdorferi in natural populations of white-footed mice, Peromyscus leucopus.

J F Anderson, R C Johnson, L A Magnarelli
PMCID: PMC269274  PMID: 3624451

Abstract

Borrelia burgdorferi, the etiologic agent of Lyme disease, was isolated from 111 of 237 Peromyscus leucopus captured during all seasons of the year. Borreliae were cultured from tissues of the spleen (101 mice), left kidney (76 mice), and right kidney (73 mice), from blood (12 mice), and from one fetus. Mice were infected during the winter, when immature Ixodes dammini were inactive. The prevalence of infection during the winter (less than or equal to 33%) was more than twofold lower than that during the summer (ca. 75%), a time when nymphal ticks are abundant. Overwintering, infected mice are reservoir hosts for subadult ticks that begin feeding in early spring. Twenty white-footed mice from which B. burgdorferi was isolated from tissues of spleen or kidney but not from blood were parasitized by larval I. dammini or Dermacentor variabilis which harbored borreliae. We conclude that these mice were infectious to feeding ticks, even though borreliae were not isolated from blood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. F., Johnson R. C., Magnarelli L. A., Hyde F. W. Identification of endemic foci of Lyme disease: isolation of Borrelia burgdorferi from feral rodents and ticks (Dermacentor variabilis). J Clin Microbiol. 1985 Jul;22(1):36–38. doi: 10.1128/jcm.22.1.36-38.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anderson J. F., Johnson R. C., Magnarelli L. A., Hyde F. W. Involvement of birds in the epidemiology of the Lyme disease agent Borrelia burgdorferi. Infect Immun. 1986 Feb;51(2):394–396. doi: 10.1128/iai.51.2.394-396.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Anderson J. F., Magnarelli L. A. Avian and mammalian hosts for spirochete-infected ticks and insects in a Lyme disease focus in Connecticut. Yale J Biol Med. 1984 Jul-Aug;57(4):627–641. [PMC free article] [PubMed] [Google Scholar]
  4. Anderson J. F., Magnarelli L. A., Burgdorfer W., Barbour A. G. Spirochetes in Ixodes dammini and mammals from Connecticut. Am J Trop Med Hyg. 1983 Jul;32(4):818–824. doi: 10.4269/ajtmh.1983.32.818. [DOI] [PubMed] [Google Scholar]
  5. Barbour A. G. Isolation and cultivation of Lyme disease spirochetes. Yale J Biol Med. 1984 Jul-Aug;57(4):521–525. [PMC free article] [PubMed] [Google Scholar]
  6. Barbour A. G., Tessier S. L., Todd W. J. Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody. Infect Immun. 1983 Aug;41(2):795–804. doi: 10.1128/iai.41.2.795-804.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bosler E. M., Coleman J. L., Benach J. L., Massey D. A., Hanrahan J. P., Burgdorfer W., Barbour A. G. Natural Distribution of the Ixodes dammini spirochete. Science. 1983 Apr 15;220(4594):321–322. doi: 10.1126/science.6836274. [DOI] [PubMed] [Google Scholar]
  8. Bosler E. M., Schulze T. L. The prevalence and significance of Borrelia burgdorferi in the urine of feral reservoir hosts. Zentralbl Bakteriol Mikrobiol Hyg A. 1986 Dec;263(1-2):40–44. doi: 10.1016/s0176-6724(86)80100-6. [DOI] [PubMed] [Google Scholar]
  9. Burgdorfer W., Barbour A. G., Hayes S. F., Benach J. L., Grunwaldt E., Davis J. P. Lyme disease-a tick-borne spirochetosis? Science. 1982 Jun 18;216(4552):1317–1319. doi: 10.1126/science.7043737. [DOI] [PubMed] [Google Scholar]
  10. Burgdorfer W., Lane R. S., Barbour A. G., Gresbrink R. A., Anderson J. R. The western black-legged tick, Ixodes pacificus: a vector of Borrelia burgdorferi. Am J Trop Med Hyg. 1985 Sep;34(5):925–930. doi: 10.4269/ajtmh.1985.34.925. [DOI] [PubMed] [Google Scholar]
  11. Burgess E. C., Amundson T. E., Davis J. P., Kaslow R. A., Edelman R. Experimental inoculation of Peromyscus spp. with Borrelia burgdorferi: evidence of contact transmission. Am J Trop Med Hyg. 1986 Mar;35(2):355–359. doi: 10.4269/ajtmh.1986.35.355. [DOI] [PubMed] [Google Scholar]
  12. Duray P. H., Johnson R. C. The histopathology of experimentally infected hamsters with the Lyme disease spirochete, Borrelia burgdorferi. Proc Soc Exp Biol Med. 1986 Feb;181(2):263–269. doi: 10.3181/00379727-181-42251. [DOI] [PubMed] [Google Scholar]
  13. Johnson R. C., Marek N., Kodner C. Infection of Syrian hamsters with Lyme disease spirochetes. J Clin Microbiol. 1984 Dec;20(6):1099–1101. doi: 10.1128/jcm.20.6.1099-1101.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Levine J. F., Wilson M. L., Spielman A. Mice as reservoirs of the Lyme disease spirochete. Am J Trop Med Hyg. 1985 Mar;34(2):355–360. doi: 10.4269/ajtmh.1985.34.355. [DOI] [PubMed] [Google Scholar]
  15. Magnarelli L. A., Anderson J. F., Chappell W. A. Geographic distribution of humans, raccoons, and white-footed mice with antibodies to Lyme disease spirochetes in Connecticut. Yale J Biol Med. 1984 Jul-Aug;57(4):619–626. [PMC free article] [PubMed] [Google Scholar]
  16. Main A. J., Carey A. B., Carey M. G., Goodwin R. H. Immature Ixodes dammini (acari: Ixodidae) on small animals in Connecticut, USA. J Med Entomol. 1982 Nov 30;19(6):655–664. doi: 10.1093/jmedent/19.6.655. [DOI] [PubMed] [Google Scholar]
  17. Spielman A., Wilson M. L., Levine J. F., Piesman J. Ecology of Ixodes dammini-borne human babesiosis and Lyme disease. Annu Rev Entomol. 1985;30:439–460. doi: 10.1146/annurev.en.30.010185.002255. [DOI] [PubMed] [Google Scholar]

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