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. 1987 Sep;25(9):1587–1590. doi: 10.1128/jcm.25.9.1587-1590.1987

Influence of lysozyme on aggregation of Staphylococcus aureus.

M R Millar 1, T Inglis 1
PMCID: PMC269288  PMID: 3654936

Abstract

The conditions under which lysozyme aggregates Staphylococcus aureus were studied. Lysozyme was found to aggregate S. aureus at concentrations found in human tear secretions. Aggregate size depended upon lysozyme concentration, ionic strength, and bacterial concentration. There was a low level of adherence of S. aureus to corneal epithelial cells, and the adherence of a recent clinical isolate was not influenced by lysozyme concentrations found in human tear secretions. Lysozyme may enhance bacterial clearance from the corneal surface of the eye by promoting particle aggregation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aly R., Shinefield H. R., Litz C., Maibach H. I. Role of teichoic acid in the binding of Staphylococcus aureus to nasal epithelial cells. J Infect Dis. 1980 Apr;141(4):463–465. doi: 10.1093/infdis/141.4.463. [DOI] [PubMed] [Google Scholar]
  2. BRUMFITT W., WARDLAW A. C., PARK J. T. Development of lysozyme-resistance in Micrococcus lysodiekticus and its association with an increased O-acetyl content of the cell wall. Nature. 1958 Jun 28;181(4626):1783–1784. doi: 10.1038/1811783a0. [DOI] [PubMed] [Google Scholar]
  3. Baum J. L. Current concepts in ophthalmology. Ocular infections. N Engl J Med. 1978 Jul 6;299(1):28–31. doi: 10.1056/NEJM197807062990107. [DOI] [PubMed] [Google Scholar]
  4. Golub E. E., Cheruka J., Boosz B., Davis C., Malamud D. A comparison of bacterial aggregation induced by saliva, lysozyme, and zinc. Infect Immun. 1985 Apr;48(1):204–210. doi: 10.1128/iai.48.1.204-210.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Iacono V. J., MacKay B. J., Grossbard B. L., DiRienzo S., Pollock J. J. Lysozyme binding by a polyglycerol phosphate polymer of the oral bacterium Streptococcus mutans BHT. Arch Oral Biol. 1982;27(4):347–354. doi: 10.1016/0003-9969(82)90165-0. [DOI] [PubMed] [Google Scholar]
  6. Laible N. J., Germaine G. R. Adsorption of lysozyme from human whole saliva by Streptococcus sanguis 903 and other oral microorganisms. Infect Immun. 1982 Apr;36(1):148–159. doi: 10.1128/iai.36.1.148-159.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McGill J. I., Liakos G. M., Goulding N., Seal D. V. Normal tear protein profiles and age-related changes. Br J Ophthalmol. 1984 May;68(5):316–320. doi: 10.1136/bjo.68.5.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Millar M. The susceptibility to lysozyme of beta-lactamase-producing and non-producing derivatives of Staphylococcus aureus strain 1030. J Med Microbiol. 1987 Mar;23(2):127–132. doi: 10.1099/00222615-23-2-127. [DOI] [PubMed] [Google Scholar]
  9. Novick R. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology. 1967 Sep;33(1):155–166. doi: 10.1016/0042-6822(67)90105-5. [DOI] [PubMed] [Google Scholar]
  10. Ofek I., Beachey E. H. Bacterial adherence. Adv Intern Med. 1980;25:503–532. [PubMed] [Google Scholar]
  11. Olsson J., Glantz P. O., Krasse B. Electrophoretic mobility of oral streptococci. Arch Oral Biol. 1976;21(10):605–609. doi: 10.1016/0003-9969(76)90030-3. [DOI] [PubMed] [Google Scholar]
  12. Reichert R., Stern G. Quantitative adherence of bacteria to human corneal epithelial cells. Arch Ophthalmol. 1984 Sep;102(9):1394–1395. doi: 10.1001/archopht.1984.01040031136041. [DOI] [PubMed] [Google Scholar]
  13. Stern G. A., Weitzenkorn D., Valenti J. Adherence of Pseudomonas aeruginosa to the mouse cornea. Epithelial v stromal adherence. Arch Ophthalmol. 1982 Dec;100(12):1956–1958. doi: 10.1001/archopht.1982.01030040936014. [DOI] [PubMed] [Google Scholar]
  14. Tellefson L. M., Germaine G. R. Adherence of Streptococcus sanguis to hydroxyapatite coated with lysozyme and lysozyme-supplemented saliva. Infect Immun. 1986 Mar;51(3):750–759. doi: 10.1128/iai.51.3.750-759.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Wecke J., Lahav M., Ginsburg I., Giesbrecht P. Cell wall degradation of Staphylococcus aureus by lysozyme. Arch Microbiol. 1982 Mar;131(2):116–123. doi: 10.1007/BF01053992. [DOI] [PubMed] [Google Scholar]

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