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. Author manuscript; available in PMC: 2009 Jun 8.
Published in final edited form as: ChemMedChem. 2008 Aug;3(8):1250–1268. doi: 10.1002/cmdc.200800047

Scheme 6.

Scheme 6

Synthesis of compounds 3646: a) Cu(OAc)2, substituted phenylboronic acids, Et3N, CH2Cl2, air, rt, 16 h; b) BBr3, CH2Cl2, −78 °C to rt, 2h; c) m-CPBA, CH2Cl2, 0 °C, 10 min; d) NaBH4, MeOH, 0 °C, 1h; e) LiOH·H2O, MeOH, H2O, rt, 2h; f) H2, Pd/C, EtOAc, rt, 2h.