Table 1.
Top 20 genes associated with benzene exposure cross-validated by Affymetrix and Illumina microarray platforms
| Affymetrix |
RefSeq ID | Illumina |
||||||
|---|---|---|---|---|---|---|---|---|
| ID | p-value* | Ratio† | Gene Title | Symbol | ID | p-value* | Ratio | |
| Downregulated (N=6) | ||||||||
| 202581_at | 3.98E-05 | 0.18 | heat shock 70kDa protein 1B | HSPA1B | NM_005346 | GI_26787974-S | 3.74E-05 | 0.19 |
| 200799_at | 6.57E-05 | 0.34 | heat shock 70kDa protein 1A | HSPA1A | NM_005345 | GI_26787973-S | 1.48E-04 | 0.32 |
| 201466_s_at | 1.47E-05 | 0.39 | v-jun sarcoma virus 17 oncogene homolog (avian) | JUN | NM_002228 | GI_44890066-S | 2.43E-05 | 0.33 |
| 208960_s_at | 1.45E-02 | 0.55 | Kruppel-like factor 6 | KLF6 | NM_001008490 | GI_37655156-S | 1.10E-04 | 0.41 |
| 229054_at | 4.37E-07 | 0.60 | FLJ39779 protein | FLJ39779 | NM_207442 | GI_42660305-S | 1.92E-04 | 0.51 |
| 202014_at | 1.33E-03 | 0.62 | protein phosphatase 1,regulatory (inhibitor) subunit 15A | PPP1R15A | NM_014330 | GI_9790902-S | 4.12E-05 | 0.55 |
| Upregulated (N=14) | ||||||||
| 201939_at | 1.05E-03 | 1.82 | polo-like kinase 2 (Drosophila) | PLK2 | NM_006622 | GI_5730054-S | 1.45E-04 | 1.62 |
| 227613_at | 8.78E-03 | 1.82 | zinc finger protein 331 | ZNF331 | NM_018555 | GI_20127571-S | 6.38E-06 | 1.62 |
| 235568_at | 5.09E-04 | 1.81 | mast cell-expressed membrane protein 1 | MCEMP1 | NM_174918 | GI_27885012-S | 9.11E-05 | 1.95 |
| 202856_s_at | 5.84E-04 | 1.76 | solute carrier family 16 member 3 | SLC16A3 | NM_004207 | GI_4759111-S | 3.99E-04 | 1.69 |
| 216248_s_at | 8.94E-03 | 1.74 | nuclear receptor subfamily 4, group A, member 2 | NR4A2 | NM_173173.1 | GI_27894352 | 3.94E-04 | 1.47 |
| 200768_s_at | 2.47E-03 | 1.64 | methionine adenosyltransferase II, alpha | MAT2A | NM_005911 | GI_34147493-S | 1.04E-04 | 1.98 |
| 218421_at | 6.52E-04 | 1.51 | ceramide kinase | CERK | NM_022766 | GI_32967302-A | 3.86E-04 | 1.40 |
| 209272_at | 2.24E-02 | 1.44 | NGFI-A binding protein 1 (EGR1 binding protein 1) | NAB1 | NM_005966 | GI_19923347-S | 2.46E-04 | 1.47 |
| 219862_s_at | 5.74E-04 | 1.38 | nuclear prelamin A recognition factor | NARF | NM_001038618 | GI_14165459-A | 1.84E-05 | 1.35 |
| 217964_at | 1.81E-02 | 1.31 | tetratricopeptide repeat domain 19 | TTC19 | NM_017775 | GI_22547158-S | 2.05E-04 | 1.37 |
| 223093_at | 2.27E-02 | 1.26 | ankylosis, progressive homolog (mouse) | ANKH | NM_054027 | GI_34452701-S | 3.99E-04 | 1.32 |
| 36554_at | 5.28E-03 | 1.25 | acetylserotonin O-methyltransferase-like | ASMTL | NM 004192 | GI_ 4757793-S | 1.02E-04 | 1.29 |
| 223740_at | 2.28E-03 | 1.24 | chromosome 6 open reading frame 59 | C6orf59 | NM_024929.1 | GI_13376403 | 3.16E-04 | 1.55 |
| 205791_x_at | 8.96E-03 | 1.23 | zinc finger protein 155, transcript variant 1 | ZNF155 | NM_198089 | GI_37655172-A | 2.63E-04 | 1.29 |
The central colums list gene title symbol, symbol and RefSeq ID, while platform-specific IDs, p-values, and differential expression ratios (relative to control) are detailed on the left (Affymetrix) and right (Illumina).
*
Raw p-values i.e. not adjusted for multiple testing are shown.
†
Differential Expression ratio.