Table 2.
Functional classification of genes modified by benzene exposure.
| GO Term | Genes† | Illumina | Affymetrix | ||
|---|---|---|---|---|---|
| p-value‡ | No. Genes | p-value‡ | No. Genes | ||
| Apoptosis | RHOB; BCL2; SPP1; CIAS1; CUL4A; TNFSF14; NFKB1; ANXA1; STK17B; PPP1R15A; TRAF3; IFI6; CTSB; MAEA; BID; TLR2; HSPA1A; MX1 | - | - | 0.0208 | 18 |
| Immune response | BCL2, CLEC5A, CXCL16, IFI6, IFNG, IL1R2, IL21R, ISG15, KLF6, MX1, PLA2G7, TNFSF14 (Overlap N = 12) | 2.58E-05 | 21 | 4.04E-14 | 37 |
| Defense response | BCL2, CD69, CLEC5A, CXCL16, HIST2H2BE, IFI6, IFNG, IL1R2, IL21R, ISG15, KLF6, MX1, PLA2G7, TNFSF14 (Overlap N = 14) | 8.23E-07 | 25 | 1.218E-13 | 39 |
| Response to stress | BCL2, CLEC5A, CXCL16, DNAJB1, DUSP1, HIST2H2BE, HSPA1A, IFI6, IFNG, ISG15, MX1, PLA2G7, PPP1R15A, SRXN1 (Overlap N = 14) | 7.26E-06 | 26 | 2.17E-06 | 35 |
| Inflammatory Response | NFKB1, CCR5, ANXA1, PLA2G7, SPP1, CIAS1, FPRL1, CHST2, CXCL16, C3AR1, TLR2, IL1R1, CD93 | - | - | 0.00121 | 13 |
| Chromatin Assembly | H2BFS; HIST1H1C; HIST2H2AC; HIST1H2AC; HIST2H2BE; HIST1H2BH; HIST2H2AA3 | 0.000819 | 7 | - | - |
*GOStat was used to assess for enrichment of GO terms among the genes with significant differential expression ≥ 1.5-fold from both the Affymetrix and Illumina analyses.
†
Genes associated with significant GO terms are listed; in the case of a GO term being associated with both platforms common genes are listed.
‡
A χ2 test is used to generate a p-value and adjustment for multiple comparisons is based on False Discovery Rate (FDR).