Table 4.
HLA allelic associations with rubella virus-specific Th1 cytokine responses.
| Locus | Allele | Allele counts | Median response (pg/ml) | First quartile (pg/ml) | Third quartile (pg/ml) | p-valuea | Global p-value |
|---|---|---|---|---|---|---|---|
| IFN-γ | Overall | 1426 | 8.53 | 2.97 | 23.41 | ||
| HLA-A | 0.082 | ||||||
| *2301 | 25 | 12.15 | 5.25 | 32.44 | 0.049 | ||
| *3301 | 9 | 3.35 | −0.97 | 12.05 | 0.023 | ||
| *6801 | 66 | 5.32 | 2.98 | 13.48 | 0.018 | ||
| HLA-B | 0.981 | ||||||
| HLA-C | 0.946 | ||||||
| HLA-DRB1 | 0.493 | ||||||
| HLA-DQA1 | 0.222 | ||||||
| HLA-DQB1 | 0.081 | ||||||
| *0302 | 161 | 11.29 | 4.25 | 23.51 | 0.069 | ||
| *0603 | 94 | 4.99 | 1.93 | 11.46 | <0.001 | ||
| HLA-DPA1 | 0.148 | ||||||
| HLA-DPB1 | 0.230 | ||||||
| IL-2 | Overall | 1426 | 17.59 | 7.73 | 30.48 | ||
| HLA-A | 0.611 | ||||||
| HLA-B | 0.141 | ||||||
| HLA-C | 0.428 | ||||||
| HLA-DRB1 | 0.123 | ||||||
| HLA-DQA1 | 0.022 | ||||||
| *0102 | 287 | 15.74 | 6.27 | 29.28 | 0.099 | ||
| *0103 | 100 | 15.16 | 4.24 | 25.73 | 0.047 | ||
| *0201 | 155 | 20.53 | 10.01 | 32.20 | 0.058 | ||
| *0301 | 147 | 21.53 | 11.40 | 35.09 | 0.005 | ||
| *0303 | 102 | 21.80 | 9.53 | 37.82 | 0.038 | ||
| HLA-DQB1 | 0.007 | ||||||
| *0202 | 116 | 19.85 | 10.01 | 34.88 | 0.077 | ||
| *0302 | 161 | 21.51 | 10.72 | 35.09 | 0.005 | ||
| *0603 | 94 | 14.34 | 2.71 | 25.63 | 0.003 | ||
| HLA-DPA1 | 0.207 | ||||||
| HLA-DPB1 | 0.382 | ||||||
| IL12-p40 | Overall | 1422 | 0.00 | −7.15 | 7.17 | ||
| HLA-A | 0.158 | ||||||
| HLA-B | 0.666 | ||||||
| HLA-C | 0.724 | ||||||
| HLA-DRB1 | 0.360 | ||||||
| HLA-DQA1 | 0.848 | ||||||
| HLA-DQB1 | 0.894 | ||||||
| HLA-DPA1 | 0.012 | ||||||
| *0103 | 1105 | 0.00 | −6.89 | 7.32 | 0.073 | ||
| *0201 | 205 | 0.00 | −9.53 | 4.96 | 0.008 | ||
| HLA-DPB1 | 0.218 |
a
Linear regression analysis. p-Values for cytokine levels were based on inverse cumulative normal transformation. Analyses adjusted for age at blood draw, gender, race, age at first rubella, age at second rubella vaccine, and cohort status. Only statistically significant or suggestive findings (p ≤ 0.10) are presented. Statistically significant global p-values are in bold type.