Abstract
Two sources of rats free of latent Pneumocystis carinii are described. First, rats from a virus-free colony failed to develop infection after 8 weeks of immune suppression unless they were housed with previously infected rats. Second, pregnant rats (non-virus free) received trimethoprim-sulfamethoxazole from day 10 of gestation until the pups were weaned. Pups raised in filter-topped cages and immunosuppressed for 8 weeks were free of P. carinii infection.
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Selected References
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- Bartlett M. S., Queener S. F., Jay M. A., Durkin M. M., Smith J. W. Improved rat model for studying Pneumocystis carinii pneumonia. J Clin Microbiol. 1987 Mar;25(3):480–484. doi: 10.1128/jcm.25.3.480-484.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Frenkel J. K., Good J. T., Shultz J. A. Latent Pneumocystis infection of rats, relapse, and chemotherapy. Lab Invest. 1966 Oct;15(10):1559–1577. [PubMed] [Google Scholar]
- Pifer L. L., Lattuada C. P., Edwards C. C., Woods D. R., Owens D. R. Pneumocystis carinii infection in germ-free rats: implications for human patients. Diagn Microbiol Infect Dis. 1984 Jan;2(1):23–36. doi: 10.1016/0732-8893(84)90020-8. [DOI] [PubMed] [Google Scholar]
- Wagner M. Absence of Pneumocystis carinii in Lobund germfree and conventional rat colonies. Prog Clin Biol Res. 1985;181:51–54. [PubMed] [Google Scholar]
- Weir E. C., Brownstein D. G., Barthold S. W. Spontaneous wasting disease in nude mice associated with Pneumocystis carinii infection. Lab Anim Sci. 1986 Apr;36(2):140–144. [PubMed] [Google Scholar]