Immunohistochemical localization of PK1 and PKR1 in third-trimester human placenta (n = 8). PK1 was immunolocalized to the syncytiotrophoblast (st) layer of placental villi, cytotrophoblasts (ct), and endothelium (e) of fetal blood vessels (bv) (A and B). PKR1 was immunolocalized to macrophages (m) in the villous core, syncytiotrophoblast (st), cytotrophoblasts (ct), and endothelium (e) (C and D). Immunohistochemistry negatives (Neg, insets) were incubated with isotype-matched IgG in place of primary antibody and displayed no immunoreactivity. Scale bars, 50 μm).