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The areas of skin reactions evoked by histamine, capsaicin and cowhage. A: Skin reactions produced in a subject by capsaicin (200 mg/ml) and histamine (10 mg/ml) but not by cowhage. Areas of wheal (B) and flare (C) reported in individual subjects tested with a capsaicin (200 mg/ml), histamine (10 mg/ml) and cowhage. Cowhage and capsaicin never evoked a wheal. D–E: Mean areas of wheal and flare obtained in response to each type of spicule.
