Table 1.
Baseline features of patients ON vs. OFF antithrombotic therapy at the time of the qualifying event (QE)
| Characteristic | ON Antithrombotic | OFF Antithrombotic | p-value |
|---|---|---|---|
| Number of patients (%) | |||
| Qualifying event | |||
| Type of event | |||
| TIA alone | 150/299 (50.2) | 72/269 (26.8) | |
| Stroke alone | 90/299 (30.1) | 150/269 (55.8) | |
| Stroke w/prior TIA | 51/299 (17.1) | 39/269 (14.5) | |
| TIA w/prior stroke | 8/299 (2.7) | 8/269 (3.0) | 0.0001 |
| Days from QE to randomization± | 31.2 (28.6) | 28.4 (27.4) | 0.2354 |
| Demographics | |||
| Male sex | 181/299 (60.5) | 169/269 (62.8) | 0.5752 |
| Race | |||
| Black | 66/299 (22.1) | 107/269 (39.8) | |
| White | 203/299 (67.9) | 128/269 (47.6) | |
| Other | 30/299 (10.0) | 34/269 (12.6) | 0.0001 |
| Age in years± | 65.3 (11.2) | 61.6 (11.3) | 0.0001 |
| Past Medical History | |||
| History of hypertension | 263/299 (88.0) | 213/267 (79.8) | 0.0079 |
| History of diabetes | 117/299 (39.1) | 99/268 (36.9) | 0.5919 |
| History of lipid disorder | 233/294 (79.2) | 157/257 (61.1) | 0.0001 |
| History of CAD | 118/294 (40.1) | 33/262 (12.6) | 0.0001 |
| History of ischemic stroke | 102/293 (34.8) | 35/263 (13.3) | 0.0001 |
| Statin use | 208/299 (69.6) | 138/269 (51.3) | 0.0001 |
| Diuretic use | 70/299 (23.4) | 62/269 (23.0) | 0.9185 |
| ACE use | 125/299 (41.8) | 108/269 (40.2) | 0.6885 |
| Smoking status | |||
| Never | 109/299 (36.4) | 93/269 (34.6) | |
| Previously | 141/299 (47.2) | 104/269 (38.7) | |
| Currently | 49/299 (16.4) | 72/269 (26.8) | 0.0079 |
| Location of Stenotic artery | |||
| ICA | 65/286 (22.7) | 54/264 (20.4) | |
| MCA | 65/286 (22.7) | 113/264 (42.8) | |
| VA | 63/286 (22.0) | 44/264 (16.7) | |
| Basilar | 69/286 (24.1) | 43/264 (16.3) | |
| Multiple | 24/286 (8.4) | 10/264 (3.8) | 0.0001 |
| % stenosis± | 63.6 (16.9) | 63.5 (15.5) | 0.9595 |
| Baseline Laboratory Values | |||
| SBP± | 139.9 (16.6) | 139.8 (17.6) | 0.9144 |
| DBP± | 76.5 (10.2) | 77.2 (10.5) | 0.3892 |
| HbA1c± | 7.4 (2.0) | 8.1 (2.5) | 0.0555 |
| HDL± | 44.5 (12.6) | 44.1 (14.1) | 0.7267 |
| LDL± | 119.4 (39.8) | 127.7 (36.3) | 0.0183 |
±
data represented in mean (standard deviation)