DEVELOPMENTAL BIOLOGY Correction for “Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development,” by Zhe Ji, Ju Youn Lee, Zhenhua Pan, Bingjun Jiang, and Bin Tian, which appeared in issue 17, April 28, 2009, of Proc Natl Acad Sci USA (106:7028–7033; first published April 16, 2009; 10.1073/pnas.0900028106).
The authors note that due to a printer's error, Fig. 1B appeared incorrectly on page 7028. The corrected figure and its legend appear below.
Fig. 1.
Alternative polyadenylation (APA) leading to alternative 3′ UTRs. (A) Schematics of APA in the 3′-most exon and using SAGE tags and Affymetrix GeneChip probes to examine APA. Two transcript variants resulting from proximal and distal poly(A) sites are shown. The dotted vertical line separates 2 UTR regions, i.e., constitutive UTR (cUTR) and alternative UTR (aUTR). CDS, coding sequence; pA, poly(A) site; AAA, poly(A) tail. (B) Distribution of length for different UTR groups. The full 3′ UTRs for genes with APA are shown by cUTR + aUTR [4,139 genes, median = 1,288 nucleotide (nt)]. Constitutive and alternative regions are represented by cUTR (median = 358 nt) and aUTR (median = 685 nt), respectively. sUTRs are 3′ UTRs not affected by APA (7,242 genes, median = 439 nt). (C) AU content for different UTR sequences.