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. 1990 Jan;28(1):156–158. doi: 10.1128/jcm.28.1.156-158.1990

Inactivation of human immunodeficiency virus type 1 in tissue culture fluid and in genital secretions by the spermicide benzalkonium chloride.

M A Wainberg 1, B Spira 1, G Bleau 1, R Thomas 1
PMCID: PMC269562  PMID: 1688873

Abstract

We have shown that the spermicidal agent benzalkonium chloride can exert a direct inhibitory effect on the viral reverse transcriptase activity of human immunodeficiency virus type 1 (HIV-1) when utilized at concentrations of 0.05% and higher. Exposure of HIV-1 to this disinfectant at concentrations of more than 0.05% was able to completely destroy viral infectivity, as assessed on susceptible target cells. We have further shown that HIV-1, which is present in both seminal and genital secretions, can be inactivated in such fluids by direct exposure to benzalkonium chloride.

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Selected References

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