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. Author manuscript; available in PMC: 2010 Mar 10.
Published in final edited form as: Biochemistry. 2009 Mar 10;48(9):1936–1944. doi: 10.1021/bi801727m

Fig. 4.

Fig. 4

The bulge causes displacement of the Tm14 signaling tip relative to the helical stalk. A) Stereoview of the superposition of Tm1143 (light seagreen and gold) and Tm14 (dark purple and light grey) reveal the repositioning of the tip by ∼25 Å as a result of a distortion in the helical stalks. Tm1143 represents how Tm14 would appear if both subunits were more symmetric. The C-alpha trace of residues 217−252 of Tm14 superimposed with a RMS of 1.7 Å . B) Stereoview of the 19 Å movement of the stalks if the conserved tips are superimposed (residues 149−164).