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. 1990 Feb;28(2):211–215. doi: 10.1128/jcm.28.2.211-215.1990

Effect of primary Epstein-Barr virus infection on human herpesvirus 6, cytomegalovirus, and measles virus immunoglobulin G titers.

A Linde 1, E Fridell 1, H Dahl 1, J Andersson 1, P Biberfeld 1, B Wahren 1
PMCID: PMC269577  PMID: 2155915

Abstract

Immunoglobulin G antibody titers to human herpesvirus 6 (HHV-6), measles virus, and cytomegalovirus (CMV) were examined in serum samples from 31 patients with Epstein-Barr virus (EBV)-induced infectious mononucleosis (IM). Sera were drawn sequentially from the same patients less than or equal to 7 days until 3 years after onset of IM. In seropositive patients, there was a significant decrease with time after IM of the immunoglobulin G titers to the three viruses in the majority of patients; HHV-6 IgG titers decreased in 80%, measles virus IgG titers decreased in 75%, and CMV IgG titers decreased in 67%. Four patients contracted CMV infection during the observation period after IM. In these, HHV-6 IgG titers increased, while EBV and measles virus IgG titers remained essentially stationary. Polyclonal B-cell stimulation during IM is suggested to augment antiviral titers in general, but the increases of HHV-6 IgG titers during EBV and CMV infections may also be due to selective stimulation of memory B cells by related antigens or to reactivation of HHV-6 during infection with these herpesviruses.

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Selected References

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  1. Andersson J., Britton S., Ernberg I., Andersson U., Henle W., Sköldenberg B., Tisell A. Effect of acyclovir on infectious mononucleosis: a double-blind, placebo-controlled study. J Infect Dis. 1986 Feb;153(2):283–290. doi: 10.1093/infdis/153.2.283. [DOI] [PubMed] [Google Scholar]
  2. Arneborn P., Biberfeld G., Forsgren M., von Stedingk L. V. Specific and non-specific B cell activation in measles and varicella. Clin Exp Immunol. 1983 Jan;51(1):165–172. [PMC free article] [PubMed] [Google Scholar]
  3. Brown N. A., Kovacs A., Lui C. R., Hur C., Zaia J. A., Mosley J. W. Prevalence of antibody to human herpesvirus 6 among blood donors infected with HIV. Lancet. 1988 Nov 12;2(8620):1146–1146. doi: 10.1016/s0140-6736(88)90570-3. [DOI] [PubMed] [Google Scholar]
  4. Efstathiou S., Gompels U. A., Craxton M. A., Honess R. W., Ward K. DNA homology between a novel human herpesvirus (HHV-6) and human cytomegalovirus. Lancet. 1988 Jan 2;1(8575-6):63–64. doi: 10.1016/s0140-6736(88)91049-5. [DOI] [PubMed] [Google Scholar]
  5. Henle W., Henle G. E., Horwitz C. A. Epstein-Barr virus specific diagnostic tests in infectious mononucleosis. Hum Pathol. 1974 Sep;5(5):551–565. doi: 10.1016/s0046-8177(74)80006-7. [DOI] [PubMed] [Google Scholar]
  6. Holmes G. P., Kaplan J. E., Stewart J. A., Hunt B., Pinsky P. F., Schonberger L. B. A cluster of patients with a chronic mononucleosis-like syndrome. Is Epstein-Barr virus the cause? JAMA. 1987 May 1;257(17):2297–2302. [PubMed] [Google Scholar]
  7. Kaschka W. P., Hilgers R., Skvaril F. Humoral immune response in Epstein-Barr virus infections. I. Elevated serum concentration of the IgG1 subclass in infectious mononucleosis and nasopharyngeal carcinoma. Clin Exp Immunol. 1982 Jul;49(1):149–156. [PMC free article] [PubMed] [Google Scholar]
  8. Krueger G. R., Koch B., Ramon A., Ablashi D. V., Salahuddin S. Z., Josephs S. F., Streicher H. Z., Gallo R. C., Habermann U. Antibody prevalence to HBLV (human herpesvirus-6, HHV-6) and suggestive pathogenicity in the general population and in patients with immune deficiency syndromes. J Virol Methods. 1988 Sep;21(1-4):125–131. doi: 10.1016/0166-0934(88)90059-6. [DOI] [PubMed] [Google Scholar]
  9. Linde A., Andersson J., Lundgren G., Wahren B. Subclass reactivity to Epstein-Barr virus capsid antigen in primary and reactivated EBV infections. J Med Virol. 1987 Feb;21(2):109–121. doi: 10.1002/jmv.1890210203. [DOI] [PubMed] [Google Scholar]
  10. Linde A., Dahl H., Wahren B., Fridell E., Salahuddin Z., Biberfeld P. IgG antibodies to human herpesvirus-6 in children and adults and in primary Epstein-Barr virus infections and cytomegalovirus infections [corrected]. J Virol Methods. 1988 Sep;21(1-4):117–123. doi: 10.1016/0166-0934(88)90058-4. [DOI] [PubMed] [Google Scholar]
  11. Niederman J. C., Liu C. R., Kaplan M. H., Brown N. A. Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet. 1988 Oct 8;2(8615):817–819. doi: 10.1016/s0140-6736(88)92783-3. [DOI] [PubMed] [Google Scholar]
  12. Pietroboni G. R., Harnett G. B., Farr T. J., Bucens M. R. Human herpes virus type 6 (HHV-6) and its in vitro effect on human immunodeficiency virus (HIV). J Clin Pathol. 1988 Dec;41(12):1310–1312. doi: 10.1136/jcp.41.12.1310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Rosén A., Gergely P., Jondal M., Klein G., Britton S. Polyclonal Ig production after Epstein-Barr virus infection of human lymphocytes in vitro. Nature. 1977 May 5;267(5606):52–54. doi: 10.1038/267052a0. [DOI] [PubMed] [Google Scholar]
  14. Salahuddin S. Z., Ablashi D. V., Markham P. D., Josephs S. F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986 Oct 31;234(4776):596–601. doi: 10.1126/science.2876520. [DOI] [PubMed] [Google Scholar]
  15. Streicher H. Z., Hung C. L., Ablashi D. V., Hellman K., Saxinger C., Fullen J., Salahuddin S. Z. In vitro inhibition of human herpesvirus-6 by phosphonoformate. J Virol Methods. 1988 Sep;21(1-4):301–304. doi: 10.1016/0166-0934(88)90075-4. [DOI] [PubMed] [Google Scholar]
  16. Sundqvist V. A., Wahren B. An interchangeable ELISA for cytomegalovirus antigen and antibody. J Virol Methods. 1981 Apr;2(5):301–312. doi: 10.1016/0166-0934(81)90029-x. [DOI] [PubMed] [Google Scholar]
  17. Walker L., Johnson G. D., MacLennan I. C. The IgG subclass responses of human lymphocytes to B-cell activators. Immunology. 1983 Oct;50(2):269–272. [PMC free article] [PubMed] [Google Scholar]

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