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. 1990 Mar;28(3):596–599. doi: 10.1128/jcm.28.3.596-599.1990

Use of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults.

J J Treanor 1, F K Roth 1, R F Betts 1
PMCID: PMC269668  PMID: 2182673

Abstract

To investigate the immunogenicity and protective efficacy of cold-adapted influenza vaccine in individuals with underlying immunity to influenza A virus, we administered cold-adapted H1N1 and H3N2 vaccines to adults with prevaccination serum hemagglutination inhibition antibody titers of 1:16 or more and challenged them 1 month afterwards with homologous wild-type influenza A virus. Both cold-adapted vaccines were immunogenic in seropositive adults. In addition, individuals receiving cold-adapted vaccines had lower rates of virus shedding and illness following challenge with wild-type influenza virus than did unvaccinated seropositive volunteers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clements M. L., Murphy B. R. Development and persistence of local and systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine. J Clin Microbiol. 1986 Jan;23(1):66–72. doi: 10.1128/jcm.23.1.66-72.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clements M. L., Tierney E. L., Murphy B. R. Response of seronegative and seropositive adult volunteers to live attenuated cold-adapted reassortant influenza A virus vaccine. J Clin Microbiol. 1985 Jun;21(6):997–999. doi: 10.1128/jcm.21.6.997-999.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Feldman S., Wright P. F., Webster R. G., Roberson P. K., Mahoney J., Thompson J., Doolittle M., Lott L., Johnson P., Christoph R. C. Use of influenza A virus vaccines in seronegative children: live cold-adapted versus inactivated whole virus. J Infect Dis. 1985 Dec;152(6):1212–1218. doi: 10.1093/infdis/152.6.1212. [DOI] [PubMed] [Google Scholar]
  4. Gorse G. J., Belshe R. B., Munn N. J. Safety of and serum antibody response to cold-recombinant influenza A and inactivated trivalent influenza virus vaccines in older adults with chronic diseases. J Clin Microbiol. 1986 Sep;24(3):336–342. doi: 10.1128/jcm.24.3.336-342.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Johnson P. R., Feldman S., Thompson J. M., Mahoney J. D., Wright P. F. Immunity to influenza A virus infection in young children: a comparison of natural infection, live cold-adapted vaccine, and inactivated vaccine. J Infect Dis. 1986 Jul;154(1):121–127. doi: 10.1093/infdis/154.1.121. [DOI] [PubMed] [Google Scholar]
  6. Johnson P. R., Jr, Feldman S., Thompson J. M., Mahoney J. D., Wright P. F. Comparison of long-term systemic and secretory antibody responses in children given live, attenuated, or inactivated influenza A vaccine. J Med Virol. 1985 Dec;17(4):325–335. doi: 10.1002/jmv.1890170405. [DOI] [PubMed] [Google Scholar]
  7. Madore H. P., Reichman R. C., Dolin R. Serum antibody responses in naturally occurring influenza A virus infection determined by enzyme-linked immunosorbent assay, hemagglutination inhibition, and complement fixation. J Clin Microbiol. 1983 Dec;18(6):1345–1350. doi: 10.1128/jcm.18.6.1345-1350.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Murphy B. R., Clements M. L., Madore H. P., Steinberg J., O'Donnell S., Betts R., Demico D., Reichman R. C., Dolin R., Maassab H. F. Dose response of cold-adapted, reassortant influenza A/California/10/78 virus (H1N1) in adult volunteers. J Infect Dis. 1984 May;149(5):816–816. doi: 10.1093/infdis/149.5.816. [DOI] [PubMed] [Google Scholar]
  9. Sears S. D., Clements M. L., Betts R. F., Maassab H. F., Murphy B. R., Snyder M. H. Comparison of live, attenuated H1N1 and H3N2 cold-adapted and avian-human influenza A reassortant viruses and inactivated virus vaccine in adults. J Infect Dis. 1988 Dec;158(6):1209–1219. doi: 10.1093/infdis/158.6.1209. [DOI] [PubMed] [Google Scholar]
  10. Treanor J. J., Betts R. F., Erb S. M., Roth F. K., Dolin R. Intranasally administered interferon as prophylaxis against experimentally induced influenza A virus infection in humans. J Infect Dis. 1987 Aug;156(2):379–383. doi: 10.1093/infdis/156.2.379. [DOI] [PubMed] [Google Scholar]
  11. Wright P. F., Okabe N., McKee K. T., Jr, Maassab H. F., Karzon D. T. Cold-adapted recombinant influenza A virus vaccines in seronegative young children. J Infect Dis. 1982 Jul;146(1):71–79. doi: 10.1093/infdis/146.1.71. [DOI] [PubMed] [Google Scholar]

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