Skip to main content
NCBI home page
Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1991 Jan;29(1):162–165. doi: 10.1128/jcm.29.1.162-165.1991

A single-season epidemic with respiratory syncytial virus subgroup B2 during 10 epidemic years, 1978 to 1988.

M A Mufson 1, B Akerlind-Stopner 1, C Orvell 1, R B Belshe 1, E Norrby 1
PMCID: PMC269722  PMID: 1993752

Abstract

Respiratory syncytial virus strains isolated from infants and children hospitalized with acute respiratory tract disease in Huntington, W. Va., from July 1979 through June 1988 were categorized by subgroup by using two panels of monoclonal antibodies specific for subgroup A and subgroup B. Of 405 strains tested, 319 (78.8%) were subgroup A, 73 (18.0%) were subgroup B1, and 13 (3.2%) were subgroup B2. The subgroup B2 strains occurred as a single-season epidemic during the epidemiologic year July 1980 to June 1981, except for one strain isolated in the epidemiologic year 1978 to 1979. Subgroup B strains were associated with significantly fewer bronchiolitis illnesses than subgroup A strains. The severity of illnesses caused by subgroup B1 and B2 strains was the same.

Full text

PDF
162

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Akerlind B., Norrby E. Occurrence of respiratory syncytial virus subtypes A and B strains in Sweden. J Med Virol. 1986 Jul;19(3):241–247. doi: 10.1002/jmv.1890190306. [DOI] [PubMed] [Google Scholar]
  2. Akerlind B., Norrby E., Orvell C., Mufson M. A. Respiratory syncytial virus: heterogeneity of subgroup B strains. J Gen Virol. 1988 Sep;69(Pt 9):2145–2154. doi: 10.1099/0022-1317-69-9-2145. [DOI] [PubMed] [Google Scholar]
  3. Anderson L. J., Hierholzer J. C., Tsou C., Hendry R. M., Fernie B. F., Stone Y., McIntosh K. Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies. J Infect Dis. 1985 Apr;151(4):626–633. doi: 10.1093/infdis/151.4.626. [DOI] [PubMed] [Google Scholar]
  4. Belshe R. B., Van Voris L. P., Mufson M. A. Parenteral administration of live respiratory syncytial virus vaccine: results of a field trial. J Infect Dis. 1982 Mar;145(3):311–319. doi: 10.1093/infdis/145.3.311. [DOI] [PubMed] [Google Scholar]
  5. COATES H. V., KENDRICK L., CHANOCK R. M. Antigenic differences between two strains of respiratory syncytial virus. Proc Soc Exp Biol Med. 1963 Apr;112:958–964. doi: 10.3181/00379727-112-28221. [DOI] [PubMed] [Google Scholar]
  6. Hendry R. M., Pierik L. T., McIntosh K. Prevalence of respiratory syncytial virus subgroups over six consecutive outbreaks: 1981-1987. J Infect Dis. 1989 Aug;160(2):185–190. doi: 10.1093/infdis/160.2.185. [DOI] [PubMed] [Google Scholar]
  7. Mufson M. A., Belshe R. B., Orvell C., Norrby E. Respiratory syncytial virus epidemics: variable dominance of subgroups A and B strains among children, 1981-1986. J Infect Dis. 1988 Jan;157(1):143–148. doi: 10.1093/infdis/157.1.143. [DOI] [PubMed] [Google Scholar]
  8. Mufson M. A., Orvell C., Rafnar B., Norrby E. Two distinct subtypes of human respiratory syncytial virus. J Gen Virol. 1985 Oct;66(Pt 10):2111–2124. doi: 10.1099/0022-1317-66-10-2111. [DOI] [PubMed] [Google Scholar]
  9. Norrby E., Mufson M. A., Sheshberadaran H. Structural differences between subtype A and B strains of respiratory syncytial virus. J Gen Virol. 1986 Dec;67(Pt 12):2721–2729. doi: 10.1099/0022-1317-67-12-2721. [DOI] [PubMed] [Google Scholar]
  10. Orvell C., Norrby E., Mufson M. A. Preparation and characterization of monoclonal antibodies directed against five structural components of human respiratory syncytial virus subgroup B. J Gen Virol. 1987 Dec;68(Pt 12):3125–3135. doi: 10.1099/0022-1317-68-12-3125. [DOI] [PubMed] [Google Scholar]
  11. Russi J. C., Delfraro A., Arbiza J. R., Chiparelli H., Orvell C., Grandien M., Hortal M. Antigenic characterization of respiratory syncytial virus associated with acute respiratory infections in Uruguayan children from 1985 to 1987. J Clin Microbiol. 1989 Jul;27(7):1464–1466. doi: 10.1128/jcm.27.7.1464-1466.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Storch G. A., Park C. S. Monoclonal antibodies demonstrate heterogeneity in the G glycoprotein of prototype strains and clinical isolates of respiratory syncytial virus. J Med Virol. 1987 Aug;22(4):345–356. doi: 10.1002/jmv.1890220407. [DOI] [PubMed] [Google Scholar]
  13. Tsutsumi H., Onuma M., Suga K., Honjo T., Chiba Y., Chiba S., Ogra P. L. Occurrence of respiratory syncytial virus subgroup A and B strains in Japan, 1980 to 1987. J Clin Microbiol. 1988 Jun;26(6):1171–1174. doi: 10.1128/jcm.26.6.1171-1174.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES