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. 2005 Mar 15;37(3):229–251. doi: 10.1186/1297-9686-37-3-229

A gene-based radiation hybrid map of chicken microchromosome 14: Comparison to human and alignment to the assembled chicken sequence

Mireille Morisson 1,✉, Sophie Leroux 1, Carine Jiguet-Jiglaire 1, Sirine Assaf 2, Frédérique Pitel 1, Sandrine Lagarrigue 2, Suzanne Bardes 1, Katia Feve 1, Thomas Faraut 1, Denis Milan 1, Alain Vignal 1
PMCID: PMC2697232  PMID: 16194526

Abstract

We present a gene-based RH map of the chicken microchromosome GGA14, known to have synteny conservations with human chromosomal regions HSA16p13.3 and HSA17p11.2. Microsatellite markers from the genetic map were used to check the validity of the RH map and additional markers were developed from chicken EST data to yield comparative mapping data. A high rate of intra-chromosomal rearrangements was detected by comparison to the assembled human sequence. Finally, the alignment of the RH map to the assembled chicken sequence showed a small number of discordances, most of which involved the same region of the chromosome spanning between 40.5 and 75.9 cR6000 on the RH map.

Keywords: chicken, comparative mapping, radiation hybrids, microchromosome 14, intrachromosomal rearrangement

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