TABLE 1.
Body weight (g) |
Blood glucose (mg/dl) | Urinary glucose (g/dl) | Albuminuria (OD/mm2) | ||
---|---|---|---|---|---|
Initial | End | ||||
Col8a1−/−/Col8a2−/− controls | 24.6 ± 1.3 | 31.4 ± 1.8 | 128.5 ± 28.7 | 0 | 0.2 ± 0 |
Col8a1−/−/Col8a2−/− STZ | 27.2 ± 3.5 | 26.9 ± 3.3* | 292.4 ± 66.6* | 3.7 ± 0.9 | 0.3 ± 0.2* |
Col8a1+/+/Col8a2+/+ controls | 26.9 ± 2.3 | 29.7 ± 2.5 | 155.7 ± 36 | 0 | 0.1 ± 0.1 |
Col8a1+/+//Col8a2+/+ STZ | 26.8 ± 3.4 | 26.2 ± 3.2† | 319 ± 61.2† | 3.8 ± 1 | 0.5 ± 0.3†‡ |
Data are means ± SD.
*P < 0.01 vs. Col8−/− controls.
†P < 0.01 vs. Col8+/+ controls.
‡P < 0.05 vs. STZ Col8[−/−.