Table 4.
Age, race, sex-adjusted difference (p-value) in cell marker variables per inter-quartile incrementa of LDL-cholesterol or use of cholesterol-lowering medication, ARIC
| Units | LDL-Cholesterol | Cholesterol lowering medication | |
|---|---|---|---|
|
Leukocyte Markers
|
|||
| Monocytes | |||
| CD14+ | MFI | 1.32 (0.06) | -2.51 (0.04) |
| CD14+ / TLR-2+ | %
MFI |
0.27 (0.49)
0.08 (0.12) |
-0.07 (0.92)
-0.07 (0.41) |
| CD14+ / TLR-4+ | %
MFI |
-0.04 (0.78)
0.12 (0.007)b |
0.23 (0.33)
-0.20 (0.001)b |
| CD14+ / CD162+ | MFI | 0.53 (0.42) | 0.47 (0.60) |
| CD45+ | MFI | -0.35 (0.37) | 0.19 (0.75) |
| CD45+ / MPO+ | MFI | 2.23 (0.02) | -2.74 (0.05) |
| Granulocytes | |||
| CD162+ | MFI | 0.96 (0.06) | -0.82 (0.32) |
| MPO+ | MFI | 20.2 (0.001)b | -28.6 (0.002)b |
| Lymphocytes | |||
| CD162+ | MFI | 0.93 (0.008)b | -0.42 (0.45) |
|
Platelet Markers
|
|||
| CD61+ | MFI | -0.88 (0.17) | 2.67 (0.009)b |
| CD61+ / CD62P+ | %
MFI |
0.70 (0.14)
0.34 (0.12) |
0.05 (0.95)
-0.48 (0.15) |
| CD41+ | MFI | 0.31 (0.51) | 0.32 (0.66) |
| CD41+ / CD154+ | %
MFI |
0.16 (0.07)
-0.04 (0.61) |
-0.06 (0.67)
-0.19 (0.14) |
|
Cell Aggregates
|
|||
| Platelet-monocyte aggregates | % gated
MFI |
0.37 (0.01)
0.08 (0.74) |
0.05 (0.84)
-0.22 (0.55) |
| Platelet-granulocyte aggregates | % gated
MFI |
0.37 (0.01)
-0.15 (0.60) |
0.00 (0.99)
0.35 (0.51) |
| Platelet-lymphocyte aggregates | % gated
MFI |
0.38 (0.01)
0.04 (0.90) |
-0.01 (0.96)
0.42 (0.36) |
LDL-cholesterol and cholesterol-lowering medications were in separate models and adjusted for age, race, and sex.
ARIC = Atherosclerosis Risk in Communities, % = percentage of positive events gated, MFI = median fluorescence intensity
a
46 mg/dL for LDL-C
b
p<0.01