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. Author manuscript; available in PMC: 2009 Jun 23.
Published in final edited form as: Autoimmunity. 2004;37(6-7):445–451. doi: 10.1080/08916930400008524

FIGURE 8.

FIGURE 8

Frequency of Ig secreting cells analyzed by ELISpot. Mean + SD frequency of antibody and autoantibody secreting B cells of the IgM and IgG isotypes from spleens of untreated and treated mice. Spleens from untreated and 12 week treated mice were analyzed at 22 weeks. Frequency is per 103 cells for total Ig and per 105 cells for anti-dsDNA Ig and anti-cardiolipin Ig. Mice treated with CTLA4Ig at 12 weeks were not different from untreated mice. Mice treated with CTLA4Ig at 9 weeks had a significantly lower frequency of Ig and autoantibody-secreting cells than untreated controls (p <0.02 for all analyses). Mice treated at 12 weeks had a lower frequency of IgG secreting cells and of anti-cardiolipin secreting cells than untreated controls (p < 0.05).