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Journal of Clinical Microbiology logoLink to Journal of Clinical Microbiology
. 1991 Oct;29(10):2331–2332. doi: 10.1128/jcm.29.10.2331-2332.1991

Superiority of methylprednisolone over dexamethasone for induction of Pneumocystis carinii infection in rats.

A Sukura 1, T Soveri 1, L A Lindberg 1
PMCID: PMC270323  PMID: 1939591

Abstract

Because of difficulties in in vitro cultivation, the basic Pneumocystis carinii studies have been carried out on animal models, mainly on rodents immunosuppressed by corticosteroids. Commonly used dexamethasone and methylprednisolone procedures were evaluated. The intensity of infection in rats was statistically significantly higher after 9 weeks' immunosuppression with methylprednisolone than with dexamethasone.

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Selected References

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