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. 1991 Nov;29(11):2666–2667. doi: 10.1128/jcm.29.11.2666-2667.1991

Nontoxigenic strains of Clostridium difficile lack the genes for both toxin A and toxin B.

A C Fluit 1, M J Wolfhagen 1, G P Verdonk 1, M Jansze 1, R Torensma 1, J Verhoef 1
PMCID: PMC270402  PMID: 1774285

Abstract

A total of 39 toxigenic and 20 nontoxigenic strains of Clostridium difficile were tested for the presence of either toxin A or toxin B by the polymerase chain reaction (PCR). All toxigenic strains produced cytotoxin as assayed by using highly sensitive fetal lung fibroblasts and were positive for toxin A as well as toxin B in the PCR assay. All nontoxigenic strains failed to produce toxin and were negative in the PCR assay. This study shows that nontoxigenic strains of Clostridium difficile lack the toxin A as well as the toxin B gene.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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