Abstract
GR69153 disk diffusion tests with 10- and 30-micrograms disks were evaluated against 383 rapidly growing aerobic pathogens. Very high absolute agreement (96.1 to 98.1%) was observed between the MICs and disk zone diameters, and no false-susceptible results were encountered with the proposed criteria. The 30-micrograms GR69153 disk with a susceptible-zone diameter of greater than or equal to 17 mm (MIC correlate, less than or equal to 8 micrograms/ml) and a resistant-zone diameter of less than or equal to 13 mm (MIC correlate, greater than 16 micrograms/ml) is recommended. GR69153 had a spectrum of activity slightly wider than that of ceftazidime against the species tested.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chin N. X., Gu J. W., Fang W., Neu H. C. In vitro activity and beta-lactamase stability of GR69153, a new long-acting cephalosporin. Antimicrob Agents Chemother. 1991 Feb;35(2):259–266. doi: 10.1128/aac.35.2.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Curtis N. A., Eisenstadt R. L., East S. J., Cornford R. J., Walker L. A., White A. J. Iron-regulated outer membrane proteins of Escherichia coli K-12 and mechanism of action of catechol-substituted cephalosporins. Antimicrob Agents Chemother. 1988 Dec;32(12):1879–1886. doi: 10.1128/aac.32.12.1879. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Erwin M. E., Jones R. N., Barrett M. S., Briggs B. M., Johnson D. M. In vitro evaluation of GR69153, a novel catechol-substituted cephalosporin. Antimicrob Agents Chemother. 1991 May;35(5):929–937. doi: 10.1128/aac.35.5.929. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fuchs P. C., Jones R. N., Barry A. L. In vitro antibacterial spectrum of E1040 compared with those of cefpirome and ceftazidime and disk diffusion interpretive criteria for E1040. Antimicrob Agents Chemother. 1990 May;34(5):914–917. doi: 10.1128/aac.34.5.914. [DOI] [PMC free article] [PubMed] [Google Scholar]
- O'Callaghan C. H., Acred P., Harper P. B., Ryan D. M., Kirby S. M., Harding S. M. GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity. Antimicrob Agents Chemother. 1980 May;17(5):876–883. doi: 10.1128/aac.17.5.876. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silley P., Griffiths J. W., Monsey D., Harris A. M. Mode of action of GR69153, a novel catechol-substituted cephalosporin, and its interaction with the tonB-dependent iron transport system. Antimicrob Agents Chemother. 1990 Sep;34(9):1806–1808. doi: 10.1128/aac.34.9.1806. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wise R., Andrews J. M., Ashby J. P., Thornber D. In vitro activity of a catechol-substituted cephalosporin, GR69153. Antimicrob Agents Chemother. 1991 Feb;35(2):329–334. doi: 10.1128/aac.35.2.329. [DOI] [PMC free article] [PubMed] [Google Scholar]