Correction for Oak et al., Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase

MEDICAL SCIENCES Correction for “Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase,” by Jean S. Oak, Jonathan A. Deane, Michael G. Kharas, Ji Luo, Thomas E. Lane, Lewis C. Cantley, and David A. Fruman, which appeared in issue 45, November 7, 2006, of Proc Natl Acad Sci USA (103:16882–16887; first published October 27, 2006; 10.1073/pnas.0607984103).

The authors note that in Fig. 5A on page 16885, the labels IL-10 and IL-2 were switched. The corrected figure appears below.

Fig. 5.

r1ΔT/r2n mice show altered T helper differentiation and decreased regulatory T cell frequency. (A) Defective differentiation in r1ΔT/r2n CD4⁺ T cells after activation and expansion under Th2 polarizing conditions. Effector CD4⁺ T cells of the indicated genotypes were restimulated with phorbol 12-myristate 13-acetate plus ionomycin, and the percentages of cells secreting the indicated cytokines were enumerated by intracellular staining. Th2 skewing is generally incomplete in this mixed genetic background (129SvEv × C57BL/6), as in C57BL/6 and related inbred strains. (B) Six- to 8-week-old r1ΔT/r2n mice have a significant reduction (P < 0.01) in the percentage of CD4⁺CD25⁺FoxP3⁺ peripheral Treg cells in the spleen (Left) but not the thymus (Right).