Table 5.
Narrow Band Elevated-Low Frequency Coupling and Drugs
| Drug (total number using drug/ 5247) | e-LFCNB present (proportion using drug) | e-LFCNB absent (proportion using drug) | χ2, P | Drug present (e-LFCNB % TST) | Drug absent (e-LFCNB % TST) | P (t-test) |
|---|---|---|---|---|---|---|
| ACEI (699) | 0.16 | 0.13 | 11.3, 0.001 | 2.6 ± 5.9 | 1.9 ± 5.9 | 0.01 |
| Diuretics (784) | 0.17 | 0.15 | 3.1, 0.08 | 2.6 ± 7.5 | 1.9 ± 5.7 | 0.004 |
| Loop diuretic (218) | 0.05 | 0.04 | 3.8, 0.05 | 3.9 ± 10.4 | 1.9 ± 5.7 | < 0.001 |
| Digitalis (141) | 0.03 | 0.03 | 0.6, 0.43 | 2.9 ± 8 | 2 ± 5.9 | 0.08 |
| β-blockers (606) | 0.11 | 0.12 | 0.8, 0.36 | 3 ± 8.4 | 1.9 ± 5.5 | < 0.001 |
| Calcium blockers | 0.13 | 0.15 | 3.6, 0.06 | 3 ± 8.2 | 1.9 ± 5.5 | < 0.001 |
| Nitrates (134) | 0.03 | 0.03 | 0.9, 0.34 | 3.1 ± 8.6 | 2 ± 5.9 | 0.04 |
| Theophylline (93) | 0.02 | 0.02 | 0.002, 1.0 | 2.8 ± 9.6 | 2 ± 5.9 | 0.18 |
| Benzodiazepines (250) | 0.05 | 0.05 | 0.16, 0.69 | 1.6 ± 4.4 | 2 ± 6 | 0.2 |
| Antipsychotic (16) | 0.004 | 0.001 | 2.6, 0.1 | 1.9 ± 7.5 | 2 ± 6 | 0.92 |
| Antidepressant (154) | 0.02 | 0.03 | 3.1, 0.08 | 1 ± 2.3 | 1.1 ± 3.9 | 0.26 |
| Estrogen (747) | 0.09 | 0.16 | 32.4, < 0.001 | 1.1 ± 4.4 | 1.1 ± 3.7 | 0.71 |
e-LFCNB: elevated low frequency coupling, narrow band; TST: total sleep time. Estrogen effect not significant after adjusting for sex.